Evolutionary dynamics and adaptive benefits of deleterious mutations in crop gene pools.
HapMaps
crop improvement
deleterious variants
genome editing
genomic prediction
mating system
propagation
selective sweeps
wild relatives
Journal
Trends in plant science
ISSN: 1878-4372
Titre abrégé: Trends Plant Sci
Pays: England
ID NLM: 9890299
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
11
03
2022
revised:
03
12
2022
accepted:
18
01
2023
medline:
15
5
2023
pubmed:
11
2
2023
entrez:
10
2
2023
Statut:
ppublish
Résumé
Mutations with deleterious consequences in nature may be conditionally deleterious in crop plants. That is, while some genetic variants may reduce fitness under wild conditions and be subject to purifying selection, they can be under positive selection in domesticates. Such deleterious alleles can be plant breeding targets, particularly for complex traits. The difficulty of distinguishing favorable from unfavorable variants reduces the power of selection, while favorable trait variation and heterosis may be attributable to deleterious alleles. Here, we review the roles of deleterious mutations in crop breeding and discuss how they can be used as a new avenue for crop improvement with emerging genomic tools, including HapMaps and pangenome analysis, aiding the identification, removal, or exploitation of deleterious mutations.
Identifiants
pubmed: 36764870
pii: S1360-1385(23)00025-0
doi: 10.1016/j.tplants.2023.01.006
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
685-697Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.