Adding pieces to the puzzle of differentiated-to-anaplastic thyroid cancer evolution: the oncogene E2F7.
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
10 02 2023
10 02 2023
Historique:
received:
10
10
2022
accepted:
17
01
2023
revised:
13
01
2023
pubmed:
11
2
2023
medline:
15
2
2023
entrez:
10
2
2023
Statut:
epublish
Résumé
Anaplastic Thyroid Cancer (ATC) is the most aggressive and de-differentiated subtype of thyroid cancer. Many studies hypothesized that ATC derives from Differentiated Thyroid Carcinoma (DTC) through a de-differentiation process triggered by specific molecular events still largely unknown. E2F7 is an atypical member of the E2F family. Known as cell cycle inhibitor and keeper of genomic stability, in specific contexts its function is oncogenic, guiding cancer progression. We performed a meta-analysis on 279 gene expression profiles, from 8 Gene Expression Omnibus patient samples datasets, to explore the causal relationship between DTC and ATC. We defined 3 specific gene signatures describing the evolution from normal thyroid tissue to DTC and ATC and validated them in a cohort of human surgically resected ATCs collected in our Institution. We identified E2F7 as a key player in the DTC-ATC transition and showed in vitro that its down-regulation reduced ATC cells' aggressiveness features. RNA-seq and ChIP-seq profiling allowed the identification of the E2F7 specific gene program, which is mainly related to cell cycle progression and DNA repair ability. Overall, this study identified a signature describing DTC de-differentiation toward ATC subtype and unveiled an E2F7-dependent transcriptional program supporting this process.
Identifiants
pubmed: 36765037
doi: 10.1038/s41419-023-05603-8
pii: 10.1038/s41419-023-05603-8
pmc: PMC9918458
doi:
Substances chimiques
E2F7 protein, human
0
E2F7 Transcription Factor
0
Types de publication
Meta-Analysis
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
99Informations de copyright
© 2023. The Author(s).
Références
EMBO J. 2003 Dec 1;22(23):6289-98
pubmed: 14633988
Cell Death Dis. 2012 Oct 25;3:e413
pubmed: 23096114
Gland Surg. 2015 Feb;4(1):44-51
pubmed: 25713779
Br J Cancer. 2012 Sep 4;107(6):994-1000
pubmed: 22828612
Eur J Nucl Med Mol Imaging. 2016 Jul;43(7):1267-77
pubmed: 26810418
Ann Oncol. 2018 Jun 1;29(6):1454-1460
pubmed: 29648575
EMBO J. 2012 Oct 3;31(19):3871-84
pubmed: 22903062
J Biol Chem. 2003 Oct 24;278(43):42041-9
pubmed: 12893818
Int J Clin Exp Pathol. 2019 Jan 01;12(1):267-274
pubmed: 31933742
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19075-80
pubmed: 16365291
EMBO J. 2004 Dec 8;23(24):4709-16
pubmed: 15538380
J Neurosci. 2012 Jun 13;32(24):8219-30
pubmed: 22699903
J Immunol Methods. 1991 Jun 3;139(2):271-9
pubmed: 1710634
Cell. 2014 Oct 23;159(3):676-90
pubmed: 25417114
Dev Cell. 2008 Jan;14(1):62-75
pubmed: 18194653
Br J Cancer. 2015 May 12;112(10):1665-74
pubmed: 25965298
J Clin Invest. 2016 Mar 1;126(3):1052-66
pubmed: 26878173
Nucleic Acids Res. 2012 Apr;40(8):3511-23
pubmed: 22180533
Oncogene. 2005 Apr 18;24(17):2810-26
pubmed: 15838517
Nucleic Acids Res. 2017 Nov 2;45(19):11249-11267
pubmed: 28981843
Cancer Res. 2009 Mar 1;69(5):1800-8
pubmed: 19223542
Cancer Res. 2007 Nov 1;67(21):10148-58
pubmed: 17981789
Oncogene. 2018 Jan 11;37(2):271-276
pubmed: 28925392
Oncogene. 2004 Jul 1;23(30):5138-50
pubmed: 15133492
Sci Adv. 2021 Jul 28;7(31):
pubmed: 34321197
Br J Cancer. 2020 Oct;123(9):1445-1455
pubmed: 32814835
Nucleic Acids Res. 2018 Sep 28;46(17):8898-8907
pubmed: 30032296
Nucleic Acids Res. 2018 May 18;46(9):4546-4559
pubmed: 29590434
Genomics. 2019 Jul;111(4):831-839
pubmed: 29775782
Am J Pathol. 2002 Nov;161(5):1549-56
pubmed: 12414503
Oncogene. 2012 Oct 11;31(41):4490-8
pubmed: 22266856
Virchows Arch. 2021 Feb;478(2):265-281
pubmed: 32683537
J Clin Endocrinol Metab. 2015 May;100(5):E697-709
pubmed: 25675381
Int J Endocrinol. 2014;2014:790834
pubmed: 25214840
Science. 2015 Feb 20;347(6224):1257601
pubmed: 25700523
Cell Death Discov. 2021 Jun 26;7(1):156
pubmed: 34226533
Br J Cancer. 2009 Nov 17;101(10):1782-91
pubmed: 19809427
Nat Rev Endocrinol. 2017 Nov;13(11):644-660
pubmed: 28707679
Mod Pathol. 2017 Nov;30(11):1527-1537
pubmed: 28731042
Dev Cell. 2008 Jan;14(1):1-3
pubmed: 18194644
J Endocrinol Invest. 2021 Mar;44(3):403-419
pubmed: 32743746
Lancet. 2016 Dec 3;388(10061):2783-2795
pubmed: 27240885
J Bone Oncol. 2020 Feb 19;21:100282
pubmed: 32154098
EMBO Rep. 2008 Mar;9(3):252-9
pubmed: 18202719
Thyroid. 2017 Feb;27(2):236-252
pubmed: 27796151