NOX Dependent ROS Generation and Cell Metabolism.
NADPH oxidase
NOX
ROS
cell metabolism
glycolytic enzymes
metabolic reprogramming
reactive oxygen species
redox metabolism
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Jan 2023
20 Jan 2023
Historique:
received:
20
12
2022
revised:
17
01
2023
accepted:
18
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Reactive oxygen species (ROS) represent a group of high reactive molecules with dualistic natures since they can induce cytotoxicity or regulate cellular physiology. Among the ROS, the superoxide anion radical (O2·-) is a key redox signaling molecule prominently generated by the NADPH oxidase (NOX) enzyme family and by the mitochondrial electron transport chain. Notably, altered redox balance and deregulated redox signaling are recognized hallmarks of cancer and are involved in malignant progression and resistance to drugs treatment. Since oxidative stress and metabolism of cancer cells are strictly intertwined, in this review, we focus on the emerging roles of NOX enzymes as important modulators of metabolic reprogramming in cancer. The NOX family includes seven isoforms with different activation mechanisms, widely expressed in several tissues. In particular, we dissect the contribute of NOX1, NOX2, and NOX4 enzymes in the modulation of cellular metabolism and highlight their potential role as a new therapeutic target for tumor metabolism rewiring.
Identifiants
pubmed: 36768405
pii: ijms24032086
doi: 10.3390/ijms24032086
pmc: PMC9916913
pii:
doi:
Substances chimiques
NADPH Oxidases
EC 1.6.3.-
Reactive Oxygen Species
0
Superoxides
11062-77-4
NADPH Oxidase 4
EC 1.6.3.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Naples Federico II
ID : Finanziamento Ricerca di Ateneo 2020 SDPFOSAA
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