Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3
aminotransferase
cyclopentene
enamine
mechanism-based inactivators
mechanistic studies
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
23 Jan 2023
23 Jan 2023
Historique:
received:
20
12
2022
revised:
16
01
2023
accepted:
17
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Ornithine aminotransferase (OAT) is overexpressed in hepatocellular carcinoma (HCC), and we previously showed that inactivation of OAT inhibits the growth of HCC. Recently, we found that (3
Identifiants
pubmed: 36770800
pii: molecules28031133
doi: 10.3390/molecules28031133
pmc: PMC9921285
pii:
doi:
Substances chimiques
Amino Acids
0
Enzyme Inhibitors
0
Ornithine-Oxo-Acid Transaminase
EC 2.6.1.13
gamma-Aminobutyric Acid
56-12-2
Carboxylic Acids
0
Ornithine
E524N2IXA3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Foundation
ID : 1904480
Organisme : NIDA NIH HHS
ID : P30 DA018310
Pays : United States
Organisme : National Science Foundation
ID : 2015210477
Organisme : National Institutes of Health
ID : CA260250
Organisme : National Institutes of Health
ID : DA030604
Organisme : National Institutes of Health
ID : P30 DA018310
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