The Cytotoxic Effect of Curcumin in Rhabdomyosarcoma Is Associated with the Modulation of AMPK, AKT/mTOR, STAT, and p53 Signaling.
Adult
Child
Humans
Curcumin
/ pharmacology
Proto-Oncogene Proteins c-akt
/ metabolism
AMP-Activated Protein Kinases
/ metabolism
Tumor Suppressor Protein p53
/ genetics
TOR Serine-Threonine Kinases
/ metabolism
Antineoplastic Agents
/ pharmacology
Rhabdomyosarcoma
/ drug therapy
Apoptosis
Cell Line, Tumor
cancer therapy
drug design and targeting
muscle tissue
nutraceuticals
sarcoma
signal transduction
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
01 Feb 2023
01 Feb 2023
Historique:
received:
22
12
2022
revised:
11
01
2023
accepted:
28
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Approximately 7% of cancers arising in children and 1% of those arising in adults are soft tissue sarcomas (STS). Of these malignancies, rhabdomyosarcoma (RMS) is the most common. RMS survival rates using current therapeutic protocols have remained largely unchanged in the past decade. Thus, it is imperative that the main molecular drivers in RMS tumorigenesis are defined so that more precise, effective, and less toxic therapies can be designed. Curcumin, a common herbal supplement derived from plants of the
Identifiants
pubmed: 36771452
pii: nu15030740
doi: 10.3390/nu15030740
pmc: PMC9920154
pii:
doi:
Substances chimiques
Curcumin
IT942ZTH98
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
AMP-Activated Protein Kinases
EC 2.7.11.31
Tumor Suppressor Protein p53
0
TOR Serine-Threonine Kinases
EC 2.7.11.1
Antineoplastic Agents
0
MTOR protein, human
EC 2.7.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Association for Cancer Research
ID : IG-2015 17137
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