A matched case-control study of the prognosis of early breast cancer in patients with Li-Fraumeni syndrome (BREAST TP53).
Breast cancer
Hereditary
Li Fraumeni syndrome
Phenotype
TP53
Journal
Breast (Edinburgh, Scotland)
ISSN: 1532-3080
Titre abrégé: Breast
Pays: Netherlands
ID NLM: 9213011
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
15
12
2022
revised:
02
02
2023
accepted:
06
02
2023
pubmed:
12
2
2023
medline:
22
3
2023
entrez:
11
2
2023
Statut:
ppublish
Résumé
Breast cancer (BC) is the most common type of cancer in premenopausal women with germline TP53 pathogenic variants (mTP53) (Li Fraumeni syndrome - LFS). However, little is known about the BC prognosis in these patients. This study analyzed the BC-related oncologic outcomes of patients with LFS. We evaluated a cohort of LFS patients with BC in comparison with a control cohort of BC patients with no pathogenic variant in a hereditary cancer panel. The primary endpoint was recurrence-free survival (RFS). Due to the risk of second malignancies in LFS, only locoregional and distant recurrences were considered events for RFS. Secondary endpoints included rates of contralateral BC, overall survival (OS), and breast cancer-specific survival (BCSS). Forty-one patients were evaluated in the mTP53 group and 82 in the control group. Median age at BC diagnosis was 40 and 41 years, respectively. The mTP53 group received less adjuvant radiotherapy than the control group (63.4% vs 93.9%, P < 0.001). Other relevant baseline characteristics and treatment received were similar between groups. 5y-RFS rates were 79.4% in the mTP53 versus 93.6% in the control group (HR 2.43, 95%CI 0.74-8.01, P = 0.143); and were not impacted by the use of adjuvant radiotherapy. 5y-BCSS rates were 92.2% and 98.6%, respectively (HR 1.87, IC95% 0.25-13.48, P = 0.534). Our results showed no statistically significant difference in BC-related RFS and BCSS between patients with mTP53 and a control group with no pathogenic variant. Larger multicentric studies are warranted to confirm these results.
Identifiants
pubmed: 36773404
pii: S0960-9776(23)00025-5
doi: 10.1016/j.breast.2023.02.002
pmc: PMC9945780
pii:
doi:
Substances chimiques
Tumor Suppressor Protein p53
0
TP53 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
157-162Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest VP: Speaker fees and/or honoraria for consultancy or advisory functions: AstraZeneca, Daiichi-Sankyo, Novartis; Financial support for educational programs and symposia: Daiichi-Sankyo. RCB: Speaker fees and/or honoraria for consultancy or advisory functions: Daiichi-Sankyo, Nestle; Financial support for educational programs and symposia: AstraZeneca, Daiichi-Sankyo; Institutional Research Funding: Novartis, AstraZeneca. LT: Consulting or Advisory Role: Lilly, Novartis, MSD, AstraZeneca, Daiichi-Sankyo; Educational Support: Pfizer, Lilly, Zodiac, AstraZeneca; Speaker: Novartis, Roche, Pfizer, Zodiac, Lilly, MSD, AstraZeneca, Daichii-Sankyo; Institutional Research Funding: Novartis. DJBHC: Speaker fees and/or honoraria for consultancy or advisory functions: Novartis, Daiichi-Sankyo, AstraZeneca; Financial support for educational programs and symposia: Gilead. AC: Speaker fees and/or honoraria for consultancy or advisory functions: AstraZeneca, Libbs. RGC: Speaker fees and/or honoraria for consultancy or advisory functions: AstraZeneca, MSD, GSK; Financial support for educational programs and symposia: AstraZeneca.