A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
19 Jun 2023
Historique:
pubmed: 14 2 2023
medline: 14 2 2023
entrez: 13 2 2023
Statut: epublish

Résumé

Radical cure of

Identifiants

DOI: 10.1101/2023.01.31.526483 PMID: 36778461 PMC: PMC9915689
pubmed: 36778461
doi: 10.1101/2023.01.31.526483
pmc: PMC9915689
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI136511
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-031788
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201200031C
Pays : United States
Organisme : NIH HHS
ID : S10 OD026929
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom

Déclaration de conflit d'intérêts

Competing interests: TM and KC are employees of BioIVT. AH-C, ELF, and SAM are employees of the Novartis Institute for Tropical Disease, BC is an employee of MMV. All other authors have no competing interests.

Auteurs

S P Maher (SP)

Center for Tropical & Emerging Global Disease, University of Georgia; Athens, GA, 30602, USA.

M A Bakowski (MA)

Calibr, a division of The Scripps Research Institute; La Jolla, CA, 92037, USA.

A Vantaux (A)

Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia; Phnom Penh, 120 210, Cambodia.

E L Flannery (EL)

Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research; Emeryville, CA, 94608, USA.

C Andolina (C)

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit; Mae Sot, Tak, 63110, Thailand.

M Gupta (M)

Department of Molecular, Cell, and Systems Biology, University of California; Riverside, CA, 92521, USA.

Y Antonova-Koch (Y)

Calibr, a division of The Scripps Research Institute; La Jolla, CA, 92037, USA.

M Argomaniz (M)

Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA, 30602, USA.

M Cabrera-Mora (M)

International Center for Malaria Research, Education and Development, Emory Vaccine Center, Emory National Primate Research Center, Emory University; Atlanta, GA, 30329, USA.

B Campo (B)

Medicines for Malaria Venture (MMV); Geneva, 1215, Switzerland.

A T Chao (AT)

Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research; Emeryville, CA, 94608, USA.

A K Chatterjee (AK)

Calibr, a division of The Scripps Research Institute; La Jolla, CA, 92037, USA.

W T Cheng (WT)

Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA, 30602, USA.

C A Cooper (CA)

Center for Tropical & Emerging Global Disease, University of Georgia; Athens, GA, 30602, USA.

K Cottier (K)

BioIVT Inc.; Westbury, NY, 11590, USA.

M R Galinski (MR)

International Center for Malaria Research, Education and Development, Emory Vaccine Center, Emory National Primate Research Center, Emory University; Atlanta, GA, 30329, USA.
Division of Infectious Diseases, Department of Medicine, Emory University; Atlanta, GA, 30329, USA.

A Harupa-Chung (A)

Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research; Emeryville, CA, 94608, USA.

H Ji (H)

Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA, 30602, USA.

S B Joseph (SB)

Calibr, a division of The Scripps Research Institute; La Jolla, CA, 92037, USA.

T Lenz (T)

Department of Molecular, Cell, and Systems Biology, University of California; Riverside, CA, 92521, USA.

S Lonardi (S)

Department of Computer Science and Engineering, University of California; Riverside, CA, 92521, USA.

J Matheson (J)

Department of Microbiology and Immunology, University of Otago; Dunedin, 9016, New Zealand.

S A Mikolajczak (SA)

Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research; Emeryville, CA, 94608, USA.

V Padin-Irizarry (V)

Center for Tropical & Emerging Global Disease, University of Georgia; Athens, GA, 30602, USA.
Department of Biology, Clayton State University; Morrow, GA, 30260, USA.

K Pan (K)

Calibr, a division of The Scripps Research Institute; La Jolla, CA, 92037, USA.

J Peneau (J)

Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia; Phnom Penh, 120 210, Cambodia.

J Prudhomme (J)

Department of Molecular, Cell, and Systems Biology, University of California; Riverside, CA, 92521, USA.

C Roesch (C)

Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia; Phnom Penh, 120 210, Cambodia.

A A Ruberto (AA)

Center for Tropical & Emerging Global Disease, University of Georgia; Athens, GA, 30602, USA.

S S Sabnis (SS)

Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA, 30602, USA.

C L Saney (CL)

Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA, 30602, USA.

J Sattabongkot (J)

Mahidol Vivax Research Unit, Mahidol University; Bangkok, 10400, Thailand.

S Sereshki (S)

Department of Computer Science and Engineering, University of California; Riverside, CA, 92521, USA.

S Suriyakan (S)

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit; Mae Sot, Tak, 63110, Thailand.

T Moeller (T)

BioIVT Inc.; Westbury, NY, 11590, USA.

R Ubalee (R)

Department of Entomology, Armed Forces Research Institute of Medical Sciences (AFRIMS); Bangkok, 10400, Thailand.

Y Wang (Y)

Department of Chemistry, University of California; Riverside, CA, 92521.
Environmental Toxicology Graduate Program, University of California; Riverside, CA, 92521, USA.

P Wasisakun (P)

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit; Mae Sot, Tak, 63110, Thailand.

J Yin (J)

Environmental Toxicology Graduate Program, University of California; Riverside, CA, 92521, USA.

C W McNamara (CW)

Calibr, a division of The Scripps Research Institute; La Jolla, CA, 92037, USA.

C J Joyner (CJ)

Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA, 30602, USA.
International Center for Malaria Research, Education and Development, Emory Vaccine Center, Emory National Primate Research Center, Emory University; Atlanta, GA, 30329, USA.

F Nosten (F)

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit; Mae Sot, Tak, 63110, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford; Oxford, OX3 7LG, UK.

B Witkowski (B)

Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia; Phnom Penh, 120 210, Cambodia.

K G Le Roch (KG)

Department of Molecular, Cell, and Systems Biology, University of California; Riverside, CA, 92521, USA.

D E Kyle (DE)

Center for Tropical & Emerging Global Disease, University of Georgia; Athens, GA, 30602, USA.

Classifications MeSH