Elevated frequency and everyday functioning implications of vascular depression in persons with HIV disease.
Cardiovascular
Depressive symptoms
Functional impairment
Human immunodeficiency virus
IADL
Mood disorder
Journal
Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
23
10
2022
revised:
24
01
2023
accepted:
04
02
2023
pmc-release:
01
04
2024
pubmed:
14
2
2023
medline:
15
3
2023
entrez:
13
2
2023
Statut:
ppublish
Résumé
Depression and cardiovascular disease are common and associated with one another in HIV disease. This study aimed to determine the frequency and everyday functioning implications of the clinical syndrome of vascular depression among people living with HIV (PLWH). Participants in this cross-sectional study included 536 PLWH and 272 seronegative individuals who completed a biomedical and psychiatric research evaluation. Vascular depression was operationalized as the current presence of: 1) two or more vascular conditions; and 2) depression as determined by a normative elevation on the Depression/Dejection subscale of the Profile of Mood States or a diagnosis of Major Depressive Disorder per the Composite International Diagnostic Interview. Everyday functioning was measured by both self- and clinician-rated activities of daily living. A logistic regression model showed that HIV was associated with a three-fold increased risk of vascular depression, independent of potential confounding factors. A second logistic regression model within the PLWH sample showed that PLWH with vascular depression had significantly greater odds of dependence in everyday functioning as compared to PLWH with either vascular disease or depression alone. The elevated frequency of vascular depression in PLWH is consistent with the vascular depression hypothesis from the late-life depression literature. The high rate of functional dependence among PLWH with vascular depression highlights the clinical importance of prospective work on this syndrome in the context of HIV disease.
Identifiants
pubmed: 36780803
pii: S0022-3956(23)00063-8
doi: 10.1016/j.jpsychires.2023.02.003
pmc: PMC10123762
mid: NIHMS1875307
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
78-85Subventions
Organisme : NIA NIH HHS
ID : R21 AG077307
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH098607
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH073419
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG065169
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH062512
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG073172
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no conflicts of interest to report.
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