Biological Activity and Probable Mechanisms of Action of Derivatives of Tryptanthrin and Mostotrin Alkaloids.
antimicrobial activity
cell cycle blocking
quinazoline alkaloids derivatives
tumor cells
Journal
Doklady. Biochemistry and biophysics
ISSN: 1608-3091
Titre abrégé: Dokl Biochem Biophys
Pays: United States
ID NLM: 101126895
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
10
10
2022
accepted:
25
10
2022
revised:
25
10
2022
entrez:
14
2
2023
pubmed:
15
2
2023
medline:
17
2
2023
Statut:
ppublish
Résumé
The alkaloid tryptanthrin and its water-soluble derivative mostotrin exhibit high antimicrobial and antitumor activity. To develop more active and less toxic preparations, syntheses and testing of the biological activities of a number of new and/or little-studied analogs were performed. Some of them have been shown to have higher cytotoxicity against tumor and microbial cells than tryptanthrin and mostotrin. Thus, 8-fluorotryptanthrin effectively inhibits the proliferation of various tumor cell lines, namely: K-562/4, HCT-116 and HCT-116p53ko at lower concentrations than tryptanthrin, and 2,8-difluorostotrin exhibits a stronger antimicrobial effect against pathogenic bacteria S. aureus ATCC 29213 than mostotrin. It has been established that the antiproliferative properties of 8-fluorotryptanthrin and 8-fluoromostotrin are associated with their ability in nanomolar concentrations to inhibit the cell cycle of tumor cells at the stage of transition from the G
Identifiants
pubmed: 36787003
doi: 10.1134/S1607672922340105
pii: 10.1134/S1607672922340105
doi:
Substances chimiques
tryptanthrine
13220-57-0
Antineoplastic Agents
0
Alkaloids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
363-366Informations de copyright
© 2022. Pleiades Publishing, Ltd.
Références
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