A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition.

Mice Animals PPAR alpha / metabolism Diabetes Mellitus, Type 2 / drug therapy Monocarboxylic Acid Transporters PPAR-gamma Agonists PPAR gamma / metabolism Hypoglycemic Agents / pharmacology

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
09 03 2023
Historique:
pubmed: 16 2 2023
medline: 11 3 2023
entrez: 15 2 2023
Statut: ppublish

Résumé

A new series of analogues or derivatives of the previously reported PPARα/γ dual agonist LT175 allowed the identification of ligand

Identifiants

DOI: 10.1021/acs.jmedchem.2c02093 PMID: 36790935
pubmed: 36790935
doi: 10.1021/acs.jmedchem.2c02093
doi:

Substances chimiques

PPAR alpha 0
Monocarboxylic Acid Transporters 0
PPAR-gamma Agonists 0
PPAR gamma 0
Hypoglycemic Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3566-3587

Auteurs

Antonio Laghezza (A)

Dipartimento Farmacia-Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", via Orabona 4, 70125 Bari, Italy.
ORCID: 0000-0001-6221-6155

Carmen Cerchia (C)

Dipartimento di Farmacia, "Drug Discovery" Laboratory, Università degli Studi di Napoli "Federico II", via D. Montesano 49, 80131 Napoli, Italy.
ORCID: 0000-0002-6631-5000

Massimo Genovese (M)

Dipartimento di Scienze Biomediche Sperimentali e Cliniche, Sezione di Scienze Biochimiche, Università degli Studi di Firenze, Viale Morgagni 50, 50134 Firenze, Italy.

Rosalba Leuci (R)

Dipartimento Farmacia-Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", via Orabona 4, 70125 Bari, Italy.
ORCID: 0000-0002-5229-988X

Erica Pranzini (E)

Dipartimento di Scienze Biomediche Sperimentali e Cliniche, Sezione di Scienze Biochimiche, Università degli Studi di Firenze, Viale Morgagni 50, 50134 Firenze, Italy.

Alice Santi (A)

Dipartimento di Scienze Biomediche Sperimentali e Cliniche, Sezione di Scienze Biochimiche, Università degli Studi di Firenze, Viale Morgagni 50, 50134 Firenze, Italy.

Leonardo Brunetti (L)

Dipartimento Farmacia-Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", via Orabona 4, 70125 Bari, Italy.
ORCID: 0000-0002-7787-6639

Luca Piemontese (L)

Dipartimento Farmacia-Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", via Orabona 4, 70125 Bari, Italy.
ORCID: 0000-0002-7980-5818

Paolo Tortorella (P)

Dipartimento Farmacia-Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", via Orabona 4, 70125 Bari, Italy.
ORCID: 0000-0003-1358-7376

Abanish Biswas (A)

Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India.

Ravi Pratap Singh (RP)

Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India.

Suhas Tambe (S)

Adgyl Lifesciences Private Ltd., Bengaluru 560058, India.

Sudeep Ca (S)

Bioanalytical Section, Eurofins Advinus Biopharma Services India Pvt. Ltd., Bengaluru 560058, India.
ORCID: 0000-0002-2995-3986

Ashok Kumar Pattnaik (AK)

Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India.

Venkatesan Jayaprakash (V)

Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India.

Paolo Paoli (P)

Dipartimento di Scienze Biomediche Sperimentali e Cliniche, Sezione di Scienze Biochimiche, Università degli Studi di Firenze, Viale Morgagni 50, 50134 Firenze, Italy.
ORCID: 0000-0001-6448-7266

Antonio Lavecchia (A)

Dipartimento di Farmacia, "Drug Discovery" Laboratory, Università degli Studi di Napoli "Federico II", via D. Montesano 49, 80131 Napoli, Italy.
ORCID: 0000-0002-2181-8026

Fulvio Loiodice (F)

Dipartimento Farmacia-Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", via Orabona 4, 70125 Bari, Italy.
ORCID: 0000-0003-3384-574X

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A New Antidiabetic Agent Showing Short- and...
questionsmedicales.fr › Eucaryotes › Animaux › A New Antidiabetic Agent Showing Short- and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR alpha › A New Antidiabetic Agent Showing Short- and...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › A New Antidiabetic Agent Showing Short- and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'acides monocarboxyliques › A New Antidiabetic Agent Showing Short- and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Agonistes du PPAR gamma › A New Antidiabetic Agent Showing Short- and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR gamma › A New Antidiabetic Agent Showing Short- and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › A New Antidiabetic Agent Showing Short- and...