Overlapping anti-NMDAR encephalitis and multiple sclerosis: A case report and literature review.


Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2023
Historique:
received: 03 11 2022
accepted: 11 01 2023
entrez: 16 2 2023
pubmed: 17 2 2023
medline: 18 2 2023
Statut: epublish

Résumé

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune-mediated disease characterized by complicated neuropsychiatric symptoms and the detection of cerebrospinal fluid antibodies against the GluN1 subunit of the NMDAR. With the proposed clinical method, more anti-NMDAR encephalitis patients have been discovered since its first report. However, anti-NMDAR encephalitis overlapping with multiple sclerosis (MS) is rare. Herein we report a male patient with anti-NMDAR encephalitis who developed MS in mainland China. Furthermore, we summarized the characteristics of patients who were diagnosed with overlapping MS and anti-NMDAR encephalitis in previous studies. Additionally, we pioneered the use of mycophenolate mofetil in immunosuppressive therapy, providing a novel therapeutic alternative for overlapping anti-NMDAR encephalitis and MS.

Identifiants

pubmed: 36793718
doi: 10.3389/fimmu.2023.1088801
pmc: PMC9923169
doi:

Substances chimiques

Autoantibodies 0
Receptors, N-Methyl-D-Aspartate 0

Types de publication

Review Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

1088801

Informations de copyright

Copyright © 2023 Liu, Yan, Li, Zhang and Li.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Pan Liu (P)

Department of Neurology, The Central Hospital of Shaoyang, Shaoyang, Hunan, China.

Hui Yan (H)

Department of Clinical Medicine, Xiangnan University, Chenzhou, Hunan, China.

Haizhe Li (H)

Department of Neurology, The Central Hospital of Shaoyang, Shaoyang, Hunan, China.

Chunhua Zhang (C)

Department of Neurology, The Central Hospital of Shaoyang, Shaoyang, Hunan, China.

Yanfang Li (Y)

Department of Neurology, The Central Hospital of Shaoyang, Shaoyang, Hunan, China.

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Classifications MeSH