Fungal keratitis in Iran: Risk factors, clinical features, and mycological profile.
Aspergillus
Fusarium
Iran
antifungal susceptibility
fungal keratitis
risk factors
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2023
2023
Historique:
received:
09
11
2022
accepted:
16
01
2023
entrez:
16
2
2023
pubmed:
17
2
2023
medline:
18
2
2023
Statut:
epublish
Résumé
This study was intended to investigate the clinical features and predisposing factors of fungal keratitis (FK), as well as molecular identification and antifungal susceptibility of causative agents in Tehran, Iran. This cross-sectional study was carried out from April 2019 to May 2021. All fungi isolates were identified using conventional methods and were confirmed by DNA-PCR-based molecular assays. Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) was used to identify yeast species. Minimum inhibitory concentrations (MIC) of eight antifungal agents were assessed according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) microbroth dilution reference method. Fungal etiology was confirmed in 86 (7.23%) of 1189 corneal ulcers. A significant predisposing factor for FK was ocular trauma caused by plant materials. Therapeutic penetrating keratoplasty (PKP) was required in 60.4% of cases. The predominant fungal species isolated was The MIC results indicate that amphotericin B may be appropriate for treating FK caused by
Identifiants
pubmed: 36794001
doi: 10.3389/fcimb.2023.1094182
pmc: PMC9922867
doi:
Substances chimiques
Antifungal Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1094182Informations de copyright
Copyright © 2023 Soleimani, Izadi, Khodavaisy, Santos, Tehupeiory-Kooreman, Ghazvini, Hashemi, Mousavi, Aala, Abdorahimi, Aminizadeh, Abedinifar, Mahmoudi, Mohamadi, Rezaie and Verweij.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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