OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.
T cells
immune checkpoint therapy
immunotherapy
mass cytometry
predictive biomarkers
single-cell RNA sequencing
systemic immune activation
Journal
Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894
Informations de publication
Date de publication:
21 03 2023
21 03 2023
Historique:
received:
10
02
2022
revised:
07
10
2022
accepted:
20
01
2023
pubmed:
17
2
2023
medline:
25
3
2023
entrez:
16
2
2023
Statut:
ppublish
Résumé
Immune checkpoint therapy (ICT) has the power to eradicate cancer, but the mechanisms that determine effective therapy-induced immune responses are not fully understood. Here, using high-dimensional single-cell profiling, we interrogate whether the landscape of T cell states in the peripheral blood predict responses to combinatorial targeting of the OX40 costimulatory and PD-1 inhibitory pathways. Single-cell RNA sequencing and mass cytometry expose systemic and dynamic activation states of therapy-responsive CD4
Identifiants
pubmed: 36796366
pii: S2666-3791(23)00031-9
doi: 10.1016/j.xcrm.2023.100939
pmc: PMC10040386
pii:
doi:
Substances chimiques
B7-H1 Antigen
0
Receptors, Chemokine
0
Tnfrsf4 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100939Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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