Diversely
Carbonic anhydrase
N-nitrosulfonamides
X-ray crystallography
inhibitor
metalloenzymes
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
entrez:
17
2
2023
pubmed:
18
2
2023
medline:
22
2
2023
Statut:
ppublish
Résumé
Carbonic anhydrases (CAs) are a zinc metalloenzymes that catalyse the reversible hydration of carbon dioxide to bicarbonate and proton, pivotal for a wide range of biological processes. CAs are involved in numerous pathologies and thus represent valuable drug targets in the treatments of several diseases such as glaucoma, obesity, tumour, neuropathic pain, cerebral ischaemia, or as antiinfectives. In the last two decades, several efforts have been made to achieve selective CA inhibitors (CAIs) employing different drug design approaches. However,
Identifiants
pubmed: 36798036
doi: 10.1080/14756366.2023.2178430
pmc: PMC9946301
doi:
Substances chimiques
Carbonic Anhydrases
EC 4.2.1.1
Zinc
J41CSQ7QDS
Sulfonamides
0
Carbonic Anhydrase Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2178430Références
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