Execution of new trajectories toward a stable goal without a functional hippocampus.
electrophysiology
hippocampus
pharmacology
spatial learning
spatial navigation
Journal
Hippocampus
ISSN: 1098-1063
Titre abrégé: Hippocampus
Pays: United States
ID NLM: 9108167
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
revised:
06
12
2022
received:
19
06
2022
accepted:
14
12
2022
medline:
29
5
2023
pubmed:
18
2
2023
entrez:
17
2
2023
Statut:
ppublish
Résumé
The hippocampus is a critical component of a mammalian spatial navigation system, with the firing sequences of hippocampal place cells during sleep or immobility constituting a "replay" of an animal's past trajectories. A novel spatial navigation task recently revealed that such "replay" sequences of place fields can also prospectively map onto imminent new paths to a goal that occupies a stable location during each session. It was hypothesized that such "prospective replay" sequences may play a causal role in goal-directed navigation. In the present study, we query this putative causal role in finding only minimal effects of muscimol-induced inactivation of the dorsal and intermediate hippocampus on the same spatial navigation task. The concentration of muscimol used demonstrably inhibited hippocampal cell firing in vivo and caused a severe deficit in a hippocampal-dependent "episodic-like" spatial memory task in a watermaze. These findings call into question whether "prospective replay" of an imminent and direct path is actually necessary for its execution in certain navigational tasks.
Substances chimiques
Muscimol
2763-96-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
769-786Subventions
Organisme : Wellcome Trust
ID : 206491
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 207481/Z/17/Z
Pays : United Kingdom
Informations de copyright
© 2023 The Authors. Hippocampus published by Wiley Periodicals LLC.
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