Glutathione supports lipid abundance

NRF2 glutathione lipids liver oxidative stress

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
11 Feb 2023
Historique:
pubmed: 18 2 2023
medline: 18 2 2023
entrez: 17 2 2023
Statut: epublish

Résumé

Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in many diseases, but the requirement for GSH in adult tissues is unclear. To interrogate this, we developed a series of

Identifiants

DOI: 10.1101/2023.02.10.524960 PMID: 36798186 PMC: PMC9934595
pubmed: 36798186
doi: 10.1101/2023.02.10.524960
pmc: PMC9934595
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : Wellcome Trust
ID : 210890/Z/18/Z
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI150698
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR078000
Pays : United States

Déclaration de conflit d'intérêts

DECLARATION OF INTERESTS All other authors declare no competing interests.

Auteurs

Gloria Asantewaa (G)

Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Emily T Tuttle (ET)

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Nathan P Ward (NP)

Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA, 33612.

Yun Pyo Kang (YP)

Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA, 33612.

Yumi Kim (Y)

Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA, 33612.

Madeline E Kavanagh (ME)

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA, 92037.

Nomeda Girnius (N)

Department of Cell Biology, Harvard Medical School, Boston, MA, USA, 02115.

Ying Chen (Y)

Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA, 06520.

Renae Duncan (R)

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Katherine Rodriguez (K)

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Fabio Hecht (F)

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Marco Zocchi (M)

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Leonid Smorodintsev-Schiller (L)

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

TashJaé Q Scales (TQ)

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Kira Taylor (K)

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Fatemeh Alimohammadi (F)

Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA, 14642.

Zachary R Sechrist (ZR)

Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Department of Surgery and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Diana Agostini-Vulaj (D)

Department of Surgery and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Xenia L Schafer (XL)

Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Hayley Chang (H)

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Zachary Smith (Z)

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Thomas N O'Connor (TN)

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Department of Surgery and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Sarah Whelan (S)

Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK.

Laura M Selfors (LM)

Department of Cell Biology, Harvard Medical School, Boston, MA, USA, 02115.

Jett Crowdis (J)

Department of Cell Biology, Harvard Medical School, Boston, MA, USA, 02115.

G Kenneth Gray (GK)

Department of Cell Biology, Harvard Medical School, Boston, MA, USA, 02115.

Roderick T Bronson (RT)

Department of Cell Biology, Harvard Medical School, Boston, MA, USA, 02115.

Dirk Brenner (D)

Experimental & Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, 29 Rue Henri Koch, Esch-sur-Alzette, Luxembourg.
Odense Research Center for Anaphylaxis (ORCA), Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark.

Alessandro Rufini (A)

Leicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK.
Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20133, Milan, Italy.

Robert T Dirksen (RT)

Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA, 14642.

Aram F Hezel (AF)

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Aaron R Huber (AR)

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Josh Munger (J)

Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Benjamin F Cravatt (BF)

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA, 92037.

Vasilis Vasiliou (V)

Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA, 06520.

Calvin L Cole (CL)

Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Department of Surgery and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Gina M DeNicola (GM)

Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA, 33612.

Isaac S Harris (IS)

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.

Classifications MeSH