Chronic Gq activation of ventral hippocampal neurons and astrocytes differentially affects memory and behavior.

Humans Astrocytes / metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism Extinction, Psychological Fear Neurons / metabolism Hippocampus / metabolism
Astrocytes Behavior Chemogenetics Hippocampus Memory Network dysfunction

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
05 2023
Historique:
received: 15 09 2022
revised: 20 12 2022
accepted: 13 01 2023
pubmed: 22 2 2023
medline: 25 3 2023
entrez: 21 2 2023
Statut: ppublish

Résumé

Network dysfunction is implicated in numerous diseases and psychiatric disorders, and the hippocampus serves as a common origin for these abnormalities. To test the hypothesis that chronic modulation of neurons and astrocytes induces impairments in cognition, we activated the hM3D(Gq) pathway in CaMKII+ neurons or GFAP+ astrocytes within the ventral hippocampus across 3, 6, and 9 months. CaMKII-hM3Dq activation impaired fear extinction at 3 months and acquisition at 9 months. Both CaMKII-hM3Dq manipulation and aging had differential effects on anxiety and social interaction. GFAP-hM3Dq activation impacted fear memory at 6 and 9 months. GFAP-hM3Dq activation impacted anxiety in the open field only at the earliest time point. CaMKII-hM3Dq activation modified the number of microglia, while GFAP-hM3Dq activation impacted microglial morphological characteristics, but neither affected these measures in astrocytes. Overall, our study elucidates how distinct cell types can modify behavior through network dysfunction, while adding a more direct role for glia in modulating behavior.

Identifiants

DOI: 10.1016/j.neurobiolaging.2023.01.007 PMID: 36801699
pubmed: 36801699
pii: S0197-4580(23)00009-X
doi: 10.1016/j.neurobiolaging.2023.01.007
pii:
doi:

Substances chimiques

Calcium-Calmodulin-Dependent Protein Kinase Type 2 EC 2.7.11.17

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9-31

Subventions

Organisme : NIH HHS
ID : DP5 OD023106
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Rebecca L Suthard (RL)

Graduate Program for Neuroscience, Boston University, Boston, MA, USA; Department of Psychological and Brain Sciences, The Center for Systems Neuroscience, Neurophotonics Center, and Photonics Center, Boston University, Boston, MA, USA.

Alexandra L Jellinger (AL)

Department of Psychological and Brain Sciences, The Center for Systems Neuroscience, Neurophotonics Center, and Photonics Center, Boston University, Boston, MA, USA.

Michelle Surets (M)

Undergraduate Program in Neuroscience, Boston University, Boston, MA, USA.

Monika Shpokayte (M)

Graduate Program for Neuroscience, Boston University, Boston, MA, USA; Department of Psychological and Brain Sciences, The Center for Systems Neuroscience, Neurophotonics Center, and Photonics Center, Boston University, Boston, MA, USA.

Angela Y Pyo (AY)

Department of Psychological and Brain Sciences, The Center for Systems Neuroscience, Neurophotonics Center, and Photonics Center, Boston University, Boston, MA, USA.

Michelle D Buzharsky (MD)

Undergraduate Program in Neuroscience, Boston University, Boston, MA, USA.

Ryan A Senne (RA)

Graduate Program for Neuroscience, Boston University, Boston, MA, USA; Department of Psychological and Brain Sciences, The Center for Systems Neuroscience, Neurophotonics Center, and Photonics Center, Boston University, Boston, MA, USA.

Kaitlyn Dorst (K)

Graduate Program for Neuroscience, Boston University, Boston, MA, USA; Department of Psychological and Brain Sciences, The Center for Systems Neuroscience, Neurophotonics Center, and Photonics Center, Boston University, Boston, MA, USA.

Heloise Leblanc (H)

Graduate Program for Neuroscience, Boston University, Boston, MA, USA; Department of Psychological and Brain Sciences, The Center for Systems Neuroscience, Neurophotonics Center, and Photonics Center, Boston University, Boston, MA, USA.

Steve Ramirez (S)

Department of Biomedical Engineering, Boston University, Boston, MA, USA; Department of Psychological and Brain Sciences, The Center for Systems Neuroscience, Neurophotonics Center, and Photonics Center, Boston University, Boston, MA, USA. Electronic address: dvsteve@bu.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chronic Gq activation of ventral hippocampal...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Chronic Gq activation of ventral hippocampal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Calcium-Calmodulin-Dependent Protein Kinases › Calcium-Calmodulin-Dependent Protein Kinase Type 2 › Chronic Gq activation of ventral hippocampal...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Renforcement (psychologie) › Extinction (psychologie) › Chronic Gq activation of ventral hippocampal...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Peur › Chronic Gq activation of ventral hippocampal...
questionsmedicales.fr › Cellules › Neurones › Chronic Gq activation of ventral hippocampal...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Chronic Gq activation of ventral hippocampal...