Regulation of human endothelial cell migration by oral contraceptive estrogen receptor ligands.
Angiogenesis
Endothelial cells
Estetrol
Ethinylestradiol
FAK Y397
GPER
PFKFB3
Journal
European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354
Informations de publication
Date de publication:
15 Apr 2023
15 Apr 2023
Historique:
received:
30
08
2022
revised:
13
02
2023
accepted:
15
02
2023
pubmed:
23
2
2023
medline:
22
3
2023
entrez:
22
2
2023
Statut:
ppublish
Résumé
Ethinylestradiol (EE) and estetrol (E4) are the two main estrogenic agents used in combined oral contraceptives. These compounds have different binding affinity to and efficacy on estrogen receptors (ER) subtypes. We previously reported that treatment with estrogenic agents enhances angiogenesis via nongenomic, G protein-coupled estrogen receptor (GPER)-dependent mechanisms. However, the impact of EE and E4 on human endothelial function has been little investigated. EE and E4 (10
Identifiants
pubmed: 36804546
pii: S0014-2999(23)00102-4
doi: 10.1016/j.ejphar.2023.175591
pii:
doi:
Substances chimiques
Receptors, Estrogen
0
Ethinyl Estradiol
423D2T571U
Estrogens
0
Contraceptives, Oral, Combined
0
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
175591Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.