Pathways of MHC I cross-presentation of exogenous antigens.
Antigen presentation
Cross-presentation
MHC I
Phagosome
Journal
Seminars in immunology
ISSN: 1096-3618
Titre abrégé: Semin Immunol
Pays: England
ID NLM: 9009458
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
01
09
2022
revised:
02
02
2023
accepted:
02
02
2023
pmc-release:
01
03
2024
pubmed:
23
2
2023
medline:
21
3
2023
entrez:
22
2
2023
Statut:
ppublish
Résumé
Phagocytes, particularly dendritic cells (DCs), generate peptide-major histocompatibility complex (MHC) I complexes from antigens they have collected from cells in tissues and report this information to CD8 T cells in a process called cross-presentation. This process allows CD8 T cells to detect, respond and eliminate abnormal cells, such as cancers or cells infected with viruses or intracellular microbes. In some settings, cross-presentation can help tolerize CD8 T cells to self-antigens. One of the principal ways that DCs acquire tissue antigens is by ingesting this material through phagocytosis. The resulting phagosomes are key hubs in the cross-presentation (XPT) process and in fact experimentally conferring the ability to phagocytize antigens can be sufficient to allow non-professional antigen presenting cells (APCs) to cross-present. Once in phagosomes, exogenous antigens can be cross-presented (XPTed) through three distinct pathways. There is a vacuolar pathway in which peptides are generated and then bind to MHC I molecules within the confines of the vacuole. Ingested exogenous antigens can also be exported from phagosomes to the cytosol upon vesicular rupture and/or possibly transport. Once in the cytosol, the antigen is degraded by the proteasome and the resulting oligopeptides can be transported to MHC I molecule in the endoplasmic reticulum (ER) (a phagosome-to-cytosol (P2C) pathway) or in phagosomes (a phagosome-to-cytosol-to-phagosome (P2C2P) pathway). Here we review how phagosomes acquire the necessary molecular components that support these three mechanisms and the contribution of these pathways. We describe what is known as well as the gaps in our understanding of these processes.
Identifiants
pubmed: 36804685
pii: S1044-5323(23)00020-9
doi: 10.1016/j.smim.2023.101729
pmc: PMC10023513
mid: NIHMS1879164
pii:
doi:
Substances chimiques
Histocompatibility Antigens Class I
0
Antigens
0
Histocompatibility Antigens
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
101729Subventions
Organisme : NIAID NIH HHS
ID : R01 AI114495
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145932
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA247624
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI095213
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declarations of interest None.
Références
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3393-8
pubmed: 23401531
Science. 1990 Aug 24;249(4971):918-21
pubmed: 2392683
Sci Rep. 2016 Feb 24;6:22064
pubmed: 26907999
J Immunol. 1999 Nov 1;163(9):4721-7
pubmed: 10528170
J Exp Med. 1986 Apr 1;163(4):903-21
pubmed: 3485173
J Immunol. 2007 Feb 15;178(4):2241-8
pubmed: 17277129
Science. 2009 Jul 10;325(5937):213-7
pubmed: 19498108
EMBO Rep. 2011 Dec 01;12(12):1257-64
pubmed: 22037009
Ann N Y Acad Sci. 2010 Jan;1183:237-50
pubmed: 20146719
Nat Immunol. 2002 Dec;3(12):1169-76
pubmed: 12436109
Cell Rep. 2017 Jun 27;19(13):2645-2656
pubmed: 28658614
Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14556-61
pubmed: 22908282
Immunol Rev. 1999 Dec;172:21-8
pubmed: 10631934
J Immunol. 1992 Mar 1;148(5):1451-7
pubmed: 1538130
Nat Immunol. 2008 Aug;9(8):847-56
pubmed: 18604214
Front Immunol. 2022 May 16;13:878271
pubmed: 35651601
Immunity. 2004 Aug;21(2):155-65
pubmed: 15308097
Front Cell Dev Biol. 2020 Dec 11;8:585713
pubmed: 33425891
Nature. 1991 Dec 5;354(6352):392-4
pubmed: 1956401
Sci Immunol. 2021 May 7;6(59):
pubmed: 33963060
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12716-21
pubmed: 22802630
J Immunol. 2000 Jan 1;164(1):168-75
pubmed: 10605008
Nature. 2017 Nov 23;551(7681):525-528
pubmed: 29107940
Mol Immunol. 2015 Dec;68(2 Pt A):112-5
pubmed: 26005101
Nat Immunol. 2000 Sep;1(3):234-8
pubmed: 10973281
Cell. 2011 Dec 9;147(6):1355-68
pubmed: 22153078
J Immunol. 2016 Feb 15;196(4):1711-20
pubmed: 26792804
Front Immunol. 2020 Jul 08;11:1276
pubmed: 32733446
Front Immunol. 2018 Dec 13;9:2806
pubmed: 30619244
Science. 2007 Jan 5;315(5808):107-11
pubmed: 17204652
J Immunol. 1996 Nov 15;157(10):4503-10
pubmed: 8906828
J Immunol. 1997 Mar 15;158(6):2723-30
pubmed: 9058806
Nature. 1990 Aug 2;346(6283):476-80
pubmed: 2198471
J Immunol. 2006 Jun 1;176(11):6770-6
pubmed: 16709836
Nat Rev Mol Cell Biol. 2009 Sep;10(9):597-608
pubmed: 19696797
Nat Immunol. 2003 Nov;4(11):1065-73
pubmed: 14566337
Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8578-83
pubmed: 8710913
Nat Med. 2001 Mar;7(3):297-303
pubmed: 11231627
PLoS One. 2020 Nov 24;15(11):e0238484
pubmed: 33232321
Trends Biochem Sci. 2017 Mar;42(3):171-179
pubmed: 27932072
Front Immunol. 2015 Jul 02;6:335
pubmed: 26191062
Sci Adv. 2021 Mar 3;7(10):
pubmed: 33658201
Immunity. 2005 Oct;23(4):409-17
pubmed: 16226506
J Immunol. 2001 Sep 1;167(5):2538-46
pubmed: 11509593
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9202-7
pubmed: 16754858
Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5910-E5919
pubmed: 28679634
Cell. 1992 Dec 24;71(7):1205-14
pubmed: 1473153
Blood. 2008 Dec 1;112(12):4712-22
pubmed: 18682599
Immunity. 2022 Jun 14;55(6):982-997.e8
pubmed: 35617964
J Exp Med. 1996 Jan 1;183(1):317-22
pubmed: 8551239
J Immunol Methods. 1998 Apr 1;213(1):53-71
pubmed: 9671125
Semin Cell Dev Biol. 2010 Jul;21(5):512-9
pubmed: 20044014
Mol Cell Proteomics. 2012 Nov;11(11):1365-77
pubmed: 22915823
Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11737-42
pubmed: 15286279
Science. 1997 Aug 29;277(5330):1306-9
pubmed: 9271576
J Immunol. 2001 Aug 1;167(3):1274-82
pubmed: 11466343
J Exp Med. 2017 Aug 7;214(8):2231-2241
pubmed: 28663435
Immunity. 1996 Apr;4(4):349-55
pubmed: 8612129
Nat Commun. 2018 Aug 6;9(1):3104
pubmed: 30082832
Trends Immunol. 2017 Sep;38(9):618-621
pubmed: 28743621
Cell Immunol. 2004 Apr;228(2):130-7
pubmed: 15219464
J Exp Med. 2016 Dec 12;213(13):2871-2883
pubmed: 27899443
Infect Immun. 2020 Jun 22;88(7):
pubmed: 32366574
Int J Nanomedicine. 2016 Aug 05;11:3753-64
pubmed: 27540289
Cell Rep. 2020 Jul 14;32(2):107905
pubmed: 32668257
J Cell Biol. 1996 Feb;132(4):585-93
pubmed: 8647890
J Leukoc Biol. 2022 Jul;112(1):157-172
pubmed: 35352390
Curr Opin Immunol. 2006 Feb;18(1):78-84
pubmed: 16338127
Nat Med. 1995 Jul;1(7):649-53
pubmed: 7585145
Elife. 2018 Jun 04;7:
pubmed: 29862966
Nat Immunol. 2021 Feb;22(2):140-153
pubmed: 33349708
J Leukoc Biol. 2017 Jul;102(1):7-17
pubmed: 28087651
Nature. 1996 Dec 5;384(6608):432-8
pubmed: 8945469
Cancer Res. 2018 Jun 15;78(12):3243-3254
pubmed: 29559473
J Immunol. 1992 Jan 1;148(1):13-8
pubmed: 1727862
Immunology. 1996 Sep;89(1):59-67
pubmed: 8911141
J Exp Med. 2006 Mar 20;203(3):647-59
pubmed: 16505142
Cell Rep. 2022 Aug 16;40(7):111205
pubmed: 35977488
Eur J Immunol. 1992 Jul;22(7):1865-9
pubmed: 1623927
Front Immunol. 2021 Jan 27;11:621931
pubmed: 33584721
PLoS One. 2015 Feb 06;10(2):e0117260
pubmed: 25658429
Biochemistry. 2012 Jun 26;51(25):4981-9
pubmed: 22668350
FEBS Lett. 2000 Jul 28;478(1-2):178-82
pubmed: 10922492
Immunity. 2022 Feb 8;55(2):308-323.e9
pubmed: 34800368
Elife. 2015 Oct 06;4:
pubmed: 26439010
Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12889-94
pubmed: 14561893
Open Biol. 2021 Nov;11(11):210194
pubmed: 34753318
Immunity. 2012 Apr 20;36(4):635-45
pubmed: 22483800
Front Immunol. 2019 Jan 07;9:3098
pubmed: 30666258
EMBO J. 2022 Mar 15;41(6):e109845
pubmed: 35170763
Immunity. 2006 Oct;25(4):607-17
pubmed: 17027300
Nat Commun. 2017 Nov 21;8(1):1640
pubmed: 29158474
EMBO J. 2005 Jul 6;24(13):2284-93
pubmed: 15973433
EMBO J. 2020 Jan 15;39(2):e102020
pubmed: 31821587
Science. 2020 Feb 7;367(6478):
pubmed: 32029601
Nature. 2006 Apr 6;440(7085):808-12
pubmed: 16489357
Immunity. 1995 Dec;3(6):783-91
pubmed: 8777723
Nature. 2004 Jun 24;429(6994):841-7
pubmed: 15215856
Nature. 1990 Jun 14;345(6276):615-8
pubmed: 2190094
J Immunol. 2017 Jan 1;198(1):249-256
pubmed: 27895179
Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9933-8
pubmed: 21628571
J Immunother. 2009 Jun;32(5):465-73
pubmed: 19609238
Mol Biol Cell. 2004 Aug;15(8):3758-70
pubmed: 15181155
Cell. 1994 Sep 9;78(5):761-71
pubmed: 8087844
J Exp Med. 1976 May 1;143(5):1283-8
pubmed: 1083422
Nature. 1993 Jan 28;361(6410):359-62
pubmed: 7678924
J Exp Med. 1996 Oct 1;184(4):1555-60
pubmed: 8879229
J Immunol. 1976 Dec;117(6):2233-8
pubmed: 825578
Methods Mol Biol. 2016;1423:183-8
pubmed: 27142017
J Cell Sci. 2018 Jul 6;131(13):
pubmed: 29980602
Elife. 2021 Dec 23;10:
pubmed: 34939932
J Immunol. 1994 Dec 1;153(11):4925-33
pubmed: 7963555
Infect Immun. 2021 Apr 16;89(5):
pubmed: 33558325
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15056-61
pubmed: 10611337
Nat Immunol. 2007 Mar;8(3):217; author reply 217-8
pubmed: 17304226
J Clin Invest. 2020 Jan 2;130(1):287-294
pubmed: 31763998
Science. 2020 Apr 24;368(6489):
pubmed: 32327568
J Biol Chem. 2008 Dec 5;283(49):33883-8
pubmed: 18819915
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23730-23741
pubmed: 32879009
Science. 2004 May 14;304(5673):1014-8
pubmed: 15143282
Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2384-9
pubmed: 21262813
J Immunol. 1996 Jun 1;156(11):4182-90
pubmed: 8666786
Int Immunol. 2005 Jan;17(1):45-53
pubmed: 15546887
J Immunol. 2012 Feb 15;188(4):1840-6
pubmed: 22238454
Front Immunol. 2018 Dec 13;9:2874
pubmed: 30619259
Annu Rev Immunol. 2013;31:443-73
pubmed: 23298205
Biochem Soc Trans. 2021 Apr 30;49(2):793-804
pubmed: 33843978
J Immunol. 2014 Oct 1;193(7):3296-307
pubmed: 25165150
Nat Cell Biol. 2007 Apr;9(4):367-78
pubmed: 17351642
Front Immunol. 2012 Mar 21;3:57
pubmed: 22566938
Nat Commun. 2017 Nov 24;8(1):1852
pubmed: 29176619
Immunol Lett. 2014 Mar-Apr;158(1-2):73-8
pubmed: 24333339
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3029-34
pubmed: 18272486
Curr Opin Immunol. 2011 Feb;23(1):119-23
pubmed: 20951016
Adv Immunol. 2002;80:1-70
pubmed: 12078479
Science. 2018 Nov 9;362(6415):694-699
pubmed: 30409884
Nature. 2009 Apr 16;458(7240):899-903
pubmed: 19219027
Curr Opin Biotechnol. 2020 Dec;66:113-122
pubmed: 32745889
Nat Immunol. 2021 Apr;22(4):497-509
pubmed: 33790474
Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16363-8
pubmed: 21930907
Nat Commun. 2018 Jun 8;9(1):2241
pubmed: 29884826
J Exp Med. 1995 Dec 1;182(6):1663-71
pubmed: 7500011
J Immunol. 2016 Nov 1;197(9):3454-3463
pubmed: 27664280
Semin Immunol. 2015 Mar;27(2):125-37
pubmed: 25887630
J Immunol. 2006 Nov 1;177(9):6018-24
pubmed: 17056526
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6092-7
pubmed: 15079077
Immunity. 2009 Jan 16;30(1):143-54
pubmed: 19144319
Immunity. 2015 May 19;42(5):850-63
pubmed: 25979419
Mol Cell Proteomics. 2012 Jul;11(7):M111.016378
pubmed: 22427703
J Immunol. 2006 Jul 15;177(2):983-90
pubmed: 16818754
Nat Immunol. 2012 Feb 05;13(3):237-45
pubmed: 22306692
Nat Commun. 2022 Sep 17;13(1):5470
pubmed: 36115831
J Immunol. 2002 Dec 15;169(12):6733-42
pubmed: 12471104
Curr Opin Immunol. 2012 Feb;24(1):119-28
pubmed: 22178549
EMBO J. 2019 Aug 15;38(16):e99266
pubmed: 31271236
Nature. 2002 Oct 3;419(6906):480-3
pubmed: 12368856
J Immunol. 2001 Mar 15;166(6):3717-23
pubmed: 11238612
Annu Rev Immunol. 1998;16:323-58
pubmed: 9597133
Cell. 1988 Sep 9;54(6):777-85
pubmed: 3261634
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15050-5
pubmed: 10611336
Immunogenetics. 1995;41(4):178-228
pubmed: 7890324
Cell. 2006 Jul 14;126(1):205-18
pubmed: 16839887
Front Immunol. 2021 Jul 15;12:680279
pubmed: 34335582
Immunity. 1996 Aug;5(2):103-14
pubmed: 8769474
Nature. 1987 Oct 8-14;329(6139):506-12
pubmed: 3309677
Front Immunol. 2015 Jan 05;5:672
pubmed: 25601867
Front Immunol. 2019 Feb 26;10:294
pubmed: 30863405
Annu Rev Biochem. 2020 Jun 20;89:605-636
pubmed: 32569521
Eur J Cell Biol. 2017 Oct;96(7):705-714
pubmed: 28688576
Curr Opin Immunol. 2020 Jun;64:1-8
pubmed: 31927332
Immunity. 2012 Apr 20;36(4):646-57
pubmed: 22483802
Immunol Lett. 2003 Oct 31;89(2-3):125-31
pubmed: 14556969
J Biol Chem. 1995 Jan 20;270(3):1443-8
pubmed: 7836413
Front Immunol. 2018 Feb 26;9:350
pubmed: 29535726
PLoS One. 2014 Feb 27;9(2):e89897
pubmed: 24587108
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3324-9
pubmed: 19218463
Nat Commun. 2022 Sep 14;13(1):5383
pubmed: 36104323
Traffic. 2010 May;11(5):675-87
pubmed: 20136776
Immunol Cell Biol. 2017 Oct;95(9):753-764
pubmed: 28559542
Front Immunol. 2020 Jan 09;10:3030
pubmed: 31998312
Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15508-13
pubmed: 25313083
J Immunol. 2012 Sep 1;189(5):2274-82
pubmed: 22821960
Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15801-6
pubmed: 19717423
Annu Rev Biophys. 2020 May 6;49:135-161
pubmed: 32004089
Nat Immunol. 2002 Dec;3(12):1177-84
pubmed: 12436110
Science. 1995 Jan 13;267(5195):243-6
pubmed: 7809629
Science. 1994 May 13;264(5161):961-5
pubmed: 7513904
Nature. 2011 Mar 31;471(7340):629-32
pubmed: 21455179
Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4942-6
pubmed: 8506338
J Exp Med. 2002 Dec 16;196(12):1627-38
pubmed: 12486105
Arch Pharm Res. 2007 Nov;30(11):1440-6
pubmed: 18087813
Nat Rev Mol Cell Biol. 2006 May;7(5):347-58
pubmed: 16633337
Curr Opin Immunol. 2021 Feb;68:1-8
pubmed: 32853880
Nature. 1999 Mar 4;398(6722):77-80
pubmed: 10078533
J Immunol. 2019 Oct 1;203(7):1730-1742
pubmed: 31492742
Curr Opin Immunol. 2016 Jun;40:43-50
pubmed: 27065088
Cell. 1986 Mar 28;44(6):959-68
pubmed: 2420472
PLoS Pathog. 2009 Apr;5(4):e1000392
pubmed: 19381260
Annu Rev Immunol. 2017 Apr 26;35:149-176
pubmed: 28125356
FEBS Lett. 2005 Feb 14;579(5):1285-90
pubmed: 15710427
Cell. 2014 Jul 31;158(3):506-21
pubmed: 25083866
Immunol Lett. 2007 Dec 15;114(2):66-72
pubmed: 17964665