Bone Fragility in Hereditary Connective Tissue Disorders: A Systematic Review and Meta-Analysis.

Humans Connective Tissue Diseases / complications Ehlers-Danlos Syndrome / complications Marfan Syndrome / complications Loeys-Dietz Syndrome / complications Osteoporosis / etiology Osteoporotic Fractures / epidemiology Connective Tissue
Ehlers-Danlos syndrome Loeys-Dietz syndrome Marfan’s syndrome fracture hereditary connective tissue disorder osteoporosis

Journal

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
ISSN: 1530-891X
Titre abrégé: Endocr Pract
Pays: United States
ID NLM: 9607439

Informations de publication

Date de publication:
Jul 2023
Historique:
received: 16 12 2022
revised: 09 02 2023
accepted: 13 02 2023
medline: 10 7 2023
pubmed: 23 2 2023
entrez: 22 2 2023
Statut: ppublish

Résumé

To investigate bone fragility in patients with hereditary connective tissue disorders (HCTD), including Ehlers-Danlos syndrome (EDS), Marfan's syndrome (MFS) and Loeys-Dietz syndrome (LDS). From inception to June 2022, potentially eligible studies were identified in the Medline and EMBASE databases using search strategy that included terms for "HCTD", "Fracture" and "Osteoporosis". Eligible studies must consist of a group of patients with HCTD and report prevalence/incidence of fracture/osteoporosis in their participants, with or without comparison with healthy individuals. Point estimates with standard errors were obtained from each study and combined using the generic inverse variance method. Among the 4206 articles identified, 19 studies were included. The pooled prevalence of fracture in EDS, MFS, and LDS were 44% (95% confidence interval [CI], 25% to 65%, I EDS was associated with fracture, which could be independent of osteoporosis status. MFS had a milder degree of increased risk of fracture and osteoporosis. Despite no data from cohort studies, there was a significantly higher rate of fracture in LDS.

Identifiants

DOI: 10.1016/j.eprac.2023.02.003 PMID: 36804968
pubmed: 36804968
pii: S1530-891X(23)00045-9
doi: 10.1016/j.eprac.2023.02.003
pii:
doi:

Types de publication

Meta-Analysis Systematic Review Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

589-600

Informations de copyright

Copyright © 2023 AACE. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure The authors have no multiplicity of interest to disclose.

Auteurs

Nipith Charoenngam (N)

Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts; Section Endocrinology, Diabetes, Nutrition and Weight Management, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts; Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address: nipith.charoenngam@gmail.com.

Thanitsara Rittiphairoj (T)

Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Ben Ponvilawan (B)

Department of Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri.

Aunchalee Jaroenlapnopparat (A)

Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts.

Palapun Waitayangkoon (P)

Department of Medicine, MetroWest Medical Center, Framingham, Massachusetts.

Pichatorn Suppakitjanusant (P)

Division of Endocrinology, Metabolism, and Lipid, Emory University School of Medicine, Atlanta, Georgia.

Vitchapong Prasitsumrit (V)

Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Chatlert Pongchaiyakul (C)

Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand.

Michael F Holick (MF)

Section Endocrinology, Diabetes, Nutrition and Weight Management, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Bone Fragility in Hereditary Connective Tissue...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies du tissu conjonctif › Bone Fragility in Hereditary Connective Tissue...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies génétiques de la peau › Syndrome d'Ehlers-Danlos › Bone Fragility in Hereditary Connective Tissue...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies du tissu conjonctif › Syndrome de Marfan › Bone Fragility in Hereditary Connective Tissue...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Syndrome de Loeys-Dietz › Bone Fragility in Hereditary Connective Tissue...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies osseuses métaboliques › Ostéoporose › Bone Fragility in Hereditary Connective Tissue...
questionsmedicales.fr › Plaies et blessures › Fractures osseuses › Fractures ostéoporotiques › Bone Fragility in Hereditary Connective Tissue...
questionsmedicales.fr › Tissus › Tissu conjonctif › Bone Fragility in Hereditary Connective Tissue...