Dosimetric benefits of adaptive radiation therapy for patients with stage III non-small cell lung cancer.

Humans Carcinoma, Non-Small-Cell Lung / pathology Lung Neoplasms / radiotherapy Radiotherapy Planning, Computer-Assisted Retrospective Studies Prospective Studies Radiotherapy Dosage Radiotherapy, Intensity-Modulated
Adaptive radiation therapy Isoeffective organ at risk sparing Isotoxic dose-escalation stage III NSCLC

Journal

Radiation oncology (London, England)
ISSN: 1748-717X
Titre abrégé: Radiat Oncol
Pays: England
ID NLM: 101265111

Informations de publication

Date de publication:
22 Feb 2023
Historique:
received: 30 09 2022
accepted: 06 02 2023
entrez: 23 2 2023
pubmed: 24 2 2023
medline: 25 2 2023
Statut: epublish

Résumé

Daily adaptive radiation therapy (ART) of patients with non-small cell lung cancer (NSCLC) lowers organs at risk exposure while maintaining the planning target volume (PTV) coverage. Thus, ART allows an isotoxic approach with increased doses to the PTV that could improve local tumor control. Herein we evaluate daily online ART strategies regarding their impact on relevant dose-volume metrics. Daily cone-beam CTs (1 × n = 28, 1 × n = 29, 11 × n = 30) of 13 stage III NSCLC patients were converted into synthetic CTs (sCTs). Treatment plans (TPs) were created retrospectively on the first-fraction sCTs (sCT Compared to the original TPs predicted dose, the median D We demonstrated that even without reducing safety margins, ART can reduce lung-doses, while still reaching adequate target coverage or escalate target doses without increasing ipsilateral lung exposure. Clinical benefits by means of toxicity and local control of both strategies should be evaluated in prospective clinical trials.

Sections du résumé

BACKGROUND BACKGROUND
Daily adaptive radiation therapy (ART) of patients with non-small cell lung cancer (NSCLC) lowers organs at risk exposure while maintaining the planning target volume (PTV) coverage. Thus, ART allows an isotoxic approach with increased doses to the PTV that could improve local tumor control. Herein we evaluate daily online ART strategies regarding their impact on relevant dose-volume metrics.
METHODS METHODS
Daily cone-beam CTs (1 × n = 28, 1 × n = 29, 11 × n = 30) of 13 stage III NSCLC patients were converted into synthetic CTs (sCTs). Treatment plans (TPs) were created retrospectively on the first-fraction sCTs (sCT
RESULTS RESULTS
Compared to the original TPs predicted dose, the median D
CONCLUSIONS CONCLUSIONS
We demonstrated that even without reducing safety margins, ART can reduce lung-doses, while still reaching adequate target coverage or escalate target doses without increasing ipsilateral lung exposure. Clinical benefits by means of toxicity and local control of both strategies should be evaluated in prospective clinical trials.

Identifiants

DOI: 10.1186/s13014-023-02222-7 PMID: 36814271 PMC: PMC9945670
pubmed: 36814271
doi: 10.1186/s13014-023-02222-7
pii: 10.1186/s13014-023-02222-7
pmc: PMC9945670
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

34

Informations de copyright

© 2023. The Author(s).

Références

J Clin Oncol. 2022 Apr 20;40(12):1301-1311
pubmed: 35108059
Radiother Oncol. 2022 Mar;168:234-240
pubmed: 35121030
Br J Radiol. 2020 Jan;93(1105):20190743
pubmed: 31670581
Semin Radiat Oncol. 2010 Apr;20(2):94-106
pubmed: 20219547
Arch Intern Med. 2009 Dec 14;169(22):2078-86
pubmed: 20008690
J Thorac Oncol. 2019 Feb;14(2):298-303
pubmed: 30292852
Int J Radiat Oncol Biol Phys. 2013 Jul 1;86(3):414-9
pubmed: 23523321
J Clin Oncol. 2017 May 1;35(13):1387-1394
pubmed: 28113017
Int J Radiat Oncol Biol Phys. 2016 Mar 1;94(3):478-92
pubmed: 26867877
Radiother Oncol. 2016 Oct;121(1):32-38
pubmed: 27647459
Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):324-33
pubmed: 16168827
Adv Radiat Oncol. 2018 Oct 18;4(1):201-209
pubmed: 30706029
Int J Radiat Oncol Biol Phys. 2011 Mar 1;79(3):901-8
pubmed: 20708850
Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):736-747
pubmed: 27639294
J Cancer Res Ther. 2021 Jan-Mar;17(1):94-98
pubmed: 33723138
J Thorac Oncol. 2017 Feb;12(2):293-301
pubmed: 27743888
Int J Radiat Oncol Biol Phys. 2017 Nov 15;99(4):994-1003
pubmed: 28916139
Med Phys. 2016 Feb;43(2):894-907
pubmed: 26843250
Phys Imaging Radiat Oncol. 2018 Sep 28;7:45-50
pubmed: 33458404
Semin Radiat Oncol. 2019 Jul;29(3):245-257
pubmed: 31027642
Med Phys. 2012 Nov;39(11):6531-3
pubmed: 23127047
Radiother Oncol. 2010 Oct;97(1):48-53
pubmed: 20832884
Phys Med. 2020 Dec;80:308-316
pubmed: 33246190
Phys Med Biol. 2019 Jul 11;64(14):145003
pubmed: 31117060
Int J Radiat Oncol Biol Phys. 2020 Apr 1;106(5):1106-1108
pubmed: 31973883
Int J Radiat Oncol Biol Phys. 2021 Apr 1;109(5):1341-1348
pubmed: 33232772
Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):425-34
pubmed: 20980108
Med Phys. 2016 Apr;43(4):1787
pubmed: 27036576
Radiother Oncol. 2017 Nov;125(2):293-300
pubmed: 29050957
JAMA Oncol. 2017 Oct 01;3(10):1358-1365
pubmed: 28570742
Phys Med Biol. 2017 Jun 7;62(11):4346-4360
pubmed: 28072395
Front Oncol. 2021 Mar 10;11:617681
pubmed: 33777759
Radiat Oncol. 2021 Nov 14;16(1):217
pubmed: 34775998
Cancer. 2005 May 15;103(10):2118-27
pubmed: 15830346
Clin Transl Radiat Oncol. 2019 Apr 26;18:140-145
pubmed: 31341990
J Clin Med. 2022 Jul 13;11(14):
pubmed: 35887808
Clin Transl Radiat Oncol. 2022 Dec 15;39:100561
pubmed: 36594078
Pract Radiat Oncol. 2022 Jul-Aug;12(4):e329-e338
pubmed: 35219879
Phys Imaging Radiat Oncol. 2019 May 01;10:35-40
pubmed: 33458266
Int J Radiat Oncol Biol Phys. 2017 Sep 1;99(1):51-60
pubmed: 28816160
Semin Radiat Oncol. 2019 Jul;29(3):198-208
pubmed: 31027637
Front Oncol. 2020 Dec 09;10:564857
pubmed: 33363005
Thorac Cancer. 2020 Jun;11(6):1375-1385
pubmed: 32323484
Radiol Oncol. 2019 Mar 3;53(1):6-14
pubmed: 30840594
Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S10-9
pubmed: 20171502
J Am Coll Cardiol. 2019 Jun 18;73(23):2976-2987
pubmed: 31196455
Int J Radiat Oncol Biol Phys. 2017 Aug 1;98(5):1142-1152
pubmed: 28721898
Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1366-1373
pubmed: 29891207
Phys Med. 2020 Aug;76:243-276
pubmed: 32736286
Phys Med Biol. 2021 May 10;66(10):
pubmed: 33862616
Med Phys. 2010 Aug;37(8):4078-101
pubmed: 20879569
Med Phys. 2018 Nov;45(11):4916-4926
pubmed: 30199101
Clin Transl Radiat Oncol. 2019 Apr 01;18:68-73
pubmed: 31341979
Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):182-183
pubmed: 27979447
J Clin Oncol. 2020 Mar 1;38(7):706-714
pubmed: 31841363
Radiother Oncol. 2018 Dec;129(3):441-448
pubmed: 30033386
Int J Radiat Oncol Biol Phys. 2017 Sep 1;99(1):70-79
pubmed: 28816165
Radiother Oncol. 2017 Aug;124(2):311-317
pubmed: 28688525
Radiat Oncol. 2018 May 16;13(1):96
pubmed: 29769103
Lancet Oncol. 2015 Feb;16(2):187-99
pubmed: 25601342

Auteurs

Lea Hoppen (L)

Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. Lea.Hoppen@umm.de.

Gustavo R Sarria (GR)

Department of Radiation Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany.

Chung S Kwok (CS)

Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Judit Boda-Heggemann (J)

Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Daniel Buergy (D)

Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Michael Ehmann (M)

Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Frank A Giordano (FA)

Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Jens Fleckenstein (J)

Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dosimetric benefits of adaptive radiation...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Dosimetric benefits of adaptive radiation...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Dosimetric benefits of adaptive radiation...
questionsmedicales.fr › Sciences de l'information › Informatique › Informatique médicale › Applications de l'informatique médicale › Prise de décision assistée par ordinateur › Thérapie assistée par ordinateur › Radiothérapie assistée par ordinateur › Planification de radiothérapie assistée par ordinateur › Dosimetric benefits of adaptive radiation...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Dosimetric benefits of adaptive radiation...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Dosimetric benefits of adaptive radiation...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Dosimétrie en radiothérapie › Dosimetric benefits of adaptive radiation...
questionsmedicales.fr › Sciences de l'information › Informatique › Informatique médicale › Applications de l'informatique médicale › Prise de décision assistée par ordinateur › Thérapie assistée par ordinateur › Radiothérapie assistée par ordinateur › Radiothérapie conformationnelle › Radiothérapie conformationnelle avec modulation d'intensité › Dosimetric benefits of adaptive radiation...