Collagenase Clostridium Histolyticum-aaes Injections for Volumetric Change of Cellulite Dimples and Gluteal Contouring.
Journal
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
ISSN: 1524-4725
Titre abrégé: Dermatol Surg
Pays: United States
ID NLM: 9504371
Informations de publication
Date de publication:
01 04 2023
01 04 2023
Historique:
medline:
17
4
2023
pubmed:
25
2
2023
entrez:
24
2
2023
Statut:
ppublish
Résumé
Collagenase clostridium histolyticum-aaes (CCH) is approved for the treatment of moderate-to-severe cellulite. This is a retrospective image review of subjects previously enrolled in Cohort 2 of the EN3835-305 trial to determine the effects of CCH on volumetric changes of cellulite dimples and overall gluteal contouring. In this retrospective analysis, photographs from Day 90 and Day 180 were superimposed on baseline images and the volumetric change of each treated cellulite dimple was quantified. Side-by-side photographs of the buttocks were also evaluated for change in gluteal contour using the Physician Global Aesthetic Improvement Scale (PGAIS). Fifty-eight female subjects and 403 cellulite dimples were evaluated. Three-dimensional imaging analysis revealed a significant improvement in total negative dimple volume at both Day 90 and Day 180 of 27% and 26%, respectively ( p < .001 and p = .002, respectively). At Day 90, the overall gluteal contour, as signified by the mean PGAIS among the 3 blinded dermatologists, was rated as +1 (improved) in 27% ( n = 17) of the subjects. At Day 180, the mean PGAIS was +1 (improved) or +2 (very much improved) in 39% ( n = 26) of the subjects. CHH is an effective tool for treating cellulite dimples and improving gluteal contour.
Sections du résumé
BACKGROUND
Collagenase clostridium histolyticum-aaes (CCH) is approved for the treatment of moderate-to-severe cellulite.
OBJECTIVE
This is a retrospective image review of subjects previously enrolled in Cohort 2 of the EN3835-305 trial to determine the effects of CCH on volumetric changes of cellulite dimples and overall gluteal contouring.
METHODS
In this retrospective analysis, photographs from Day 90 and Day 180 were superimposed on baseline images and the volumetric change of each treated cellulite dimple was quantified. Side-by-side photographs of the buttocks were also evaluated for change in gluteal contour using the Physician Global Aesthetic Improvement Scale (PGAIS).
RESULTS
Fifty-eight female subjects and 403 cellulite dimples were evaluated. Three-dimensional imaging analysis revealed a significant improvement in total negative dimple volume at both Day 90 and Day 180 of 27% and 26%, respectively ( p < .001 and p = .002, respectively). At Day 90, the overall gluteal contour, as signified by the mean PGAIS among the 3 blinded dermatologists, was rated as +1 (improved) in 27% ( n = 17) of the subjects. At Day 180, the mean PGAIS was +1 (improved) or +2 (very much improved) in 39% ( n = 26) of the subjects.
CONCLUSION
CHH is an effective tool for treating cellulite dimples and improving gluteal contour.
Identifiants
pubmed: 36826346
doi: 10.1097/DSS.0000000000003727
pii: 00042728-202304000-00013
doi:
Substances chimiques
Microbial Collagenase
EC 3.4.24.3
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
383-386Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2023 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
Références
Avram MM. Cellulite: a review of its physiology and treatment. J Cosmet Laser Ther 2004;6:181–5.
Hexsel D, Siega C, Schilling-Souza J, Stapenhorst A, et al. Assessment of psychological, psychiatric, and behavioral aspects of patients with cellulite: a pilot study. Surg Cosmet Dermatol 2012;4:131–6.
Kaufman-Janette J, Joseph JH, Kaminer MS, Clark J, et al. Collagenase Clostridium histolyticum-aaes for the treatment of cellulite in women: results from two phase 3 randomized, placebo-controlled trials. Dermatol Surg 2021;47:649–56.
Carr E, Hoss E, Kollipara R, Fabi SG. Vacuum-assisted subcision for gluteal contouring. Dermatol Surg 2021;47:294–6.
Querleux B, Cornillon C, Jolivet O, Bittoun J. Anatomy and physiology of subcutaneous adipose tissue by in vivo magnetic resonance imaging and spectroscopy: relationships with sex and presence of cellulite. Skin Res Technol 2002;8:118–24.
Hexsel D, Dal Forno T, Hexsel C, Schilling-Souza J, et al. Magnetic resonance imaging of cellulite depressed lesions successfully treated by subcision. Dermatol Surg 2016;42:693–6.
Kaminer MS, Coleman WP III, Weiss RA, Robinson DM, et al. Multicenter pivotal study of vacuum-assisted precise tissue release for the treatment of cellulite. Dermatol Surg 2015;41:336–47.
Sadick NS, Goldman MP, Liu G, Shusterman NH, et al. Collagenase Clostridium histolyticum for the treatment of edematous fibrosclerotic panniculopathy (cellulite): a randomized trial. Dermatol Surg 2019;45:1047–56.
Bass LS, Kaufman-Janette J, Joseph JH, Kaminer MS, et al. Collagenase Clostridium histolyticum-aaes for treatment of cellulite: a pooled analysis of two phase-3 trials. Plast Reconstr Surg - Glob Open 2022;10:1–12.
Day D, Burgess CM, Kircik LH, Bernstein LJ, et al. Three- dimensional analysis of minimally invasive vacuum-assisted subcision treatment of cellulite. J Drugs Dermatol 2018;17:960–5.
Hexsel DM, Abreu M, Rodrigues TC, Soirefmann M, et al. Side-by-side comparison of areas with and without cellulite depressions using magnetic resonance imaging. Dermatol Surg 2009;35:1471–7.
Nurnberger F, Muller G. So-called cellulite: an invented disease. J Dermatol Surg Oncol 1978;4:221–9.
Hoenig JF, Swetje K. Age-related ptosis of the buttock: an anthropometric gender-specific analysis. Aesthet Plast Surg 2013;37:1090–9.
Wong WW, Motakef S, Lin Y, Gupta SC. Redefining the ideal buttocks: a population analysis. Plast Reconstr Surg 2016;137:1739–47.
Mazzuco R, Sadick NS. The use of poly- l -lactic acid in the gluteal area. Dermatol Surg 2016;42:441–3.
Durairaj KK, Devgan L, Lee BS A, Khachatourian BS N, et al. Poly- l -Lactic acid for gluteal augmentation found to be safe and effective in retrospective clinical review of 60 patients. Dermatol Surg 2020;46:S46–S53.
Nikolis A, Enright K, Avelar L, Rice S, et al. A prospective, multicenter trial on the efficacy and safety of poly- l -lactic acid for the treatment of contour deformities of the buttock regions. J Drugs Dermatol 2022;21:304–8.
Harper J, Avelar L, Haddad A, Novello J, et al. Expert recommendations on the use of injectable poly-L-lactic acid for contour deficiencies of the buttocks. J Drugs Dermatol 2022;21:21–6.