Effect directed analysis of bioactive compounds in leaf extracts from two Salvia species by High-performance thin-layer chromatography.
AChE inhibitors
Antimicrobial
Bioassay guided detection
HPTLC screening
Salvia
α-Amylase
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
01 Apr 2023
01 Apr 2023
Historique:
received:
18
12
2022
revised:
14
02
2023
accepted:
19
02
2023
pubmed:
25
2
2023
medline:
21
3
2023
entrez:
24
2
2023
Statut:
ppublish
Résumé
Extracts of two Salvia species, Salvia apiana (white sage) and Salvia officinalis (common sage) were screened for phytoconstituents with the ability to act as antidiabetic, cognitive enhancing, or antimicrobial agents, by hyphenation of high-performance thin-layer chromatography with enzymatic and microbial effect directed assays. Two bioactive zones with α-amylase inhibition (zone 1 and zone 2), 3 zones for acetylcholinesterase inhibition (zones 3, 4 and 5), and two zones for antimicrobial activity (zones 4 and 5) were detected. The compounds from the five bioactive zones were initially identified by coelution with standards and comparing the R
Identifiants
pubmed: 36827737
pii: S0731-7085(23)00077-8
doi: 10.1016/j.jpba.2023.115308
pii:
doi:
Substances chimiques
Acetylcholinesterase
EC 3.1.1.7
Abietanes
0
Triterpenes
0
Anti-Infective Agents
0
Flavonoids
0
alpha-Amylases
EC 3.2.1.1
Plant Extracts
0
Antioxidants
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115308Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.