Childhood trauma is associated with altered white matter microstructural organization in schizophrenia.

Humans White Matter Schizophrenia / complications Adverse Childhood Experiences Diffusion Tensor Imaging Diffusion Magnetic Resonance Imaging
Childhood trauma Childhood trauma severity Diffusion-weighted magnetic resonance imaging Fractional anisotropy Schizophrenia Tract-based spatial statistic

Journal

Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001

Informations de publication

Date de publication:
04 2023
Historique:
received: 09 12 2022
revised: 02 02 2023
accepted: 15 02 2023
pubmed: 25 2 2023
medline: 15 3 2023
entrez: 24 2 2023
Statut: ppublish

Résumé

It has been reported that childhood trauma (CT) is associated with reductions in fractional anisotropy (FA) in individuals with schizophrenia (SZ). Here, we hypothesized that SZ with high levels of CT will show the greatest reductions in FA in frontolimbic and frontoparietal regions compared to healthy controls (HC) with high trauma levels and participants with no/low levels of CT. Thirty-seven SZ and 129 HC with CT experience were dichotomized into groups of 'none/low' or 'high' levels. Participants underwent diffusion-weighted MRI, and Tract-based spatial statistics were employed to assess the main effect of diagnosis, main effect of CT severity irrespective of diagnosis, and interaction between diagnosis and CT severity. SZ showed FA reductions in the corpus callosum and corona radiata compared to HC. Irrespective of a diagnosis, high CT levels (n = 48) were related to FA reductions in frontolimbic and frontoparietal regions compared to those with none/low levels of CT (n = 118). However, no significant interaction between diagnosis and high levels of CT was found (n = 13). Across all participants, we observed effects of CT on late developing frontolimbic and frontoparietal regions, suggesting that the effects of CT severity on white matter organization may be independent of schizophrenia.

Identifiants

DOI: 10.1016/j.pscychresns.2023.111616 PMID: 36827958
pubmed: 36827958
pii: S0925-4927(23)00026-4
doi: 10.1016/j.pscychresns.2023.111616
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111616

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors report no biomedical financial interests or potential conflicts of interest.

Auteurs

Maria R Dauvermann (MR)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland; Institute for Mental Health, School of Psychology, University of Birmingham, B15 2TT, United Kingdom. Electronic address: m.dauvermann@bham.ac.uk.

Laura Costello (L)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland.

Giulia Tronchin (G)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland.

Laurena Holleran (L)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland.

David Mothersill (D)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland; Department of Psychology, School of Business, National College of Ireland, Dublin, Ireland; Department of Psychiatry, Trinity College Dublin, St. James's Hospital, Dublin, Ireland.

Karolina I Rokita (KI)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland.

Ruán Kane (R)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland.

Brian Hallahan (B)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland.

Aiden Corvin (A)

Department of Psychology, School of Business, National College of Ireland, Dublin, Ireland.

Derek Morris (D)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland.

Declan P McKernan (DP)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland.

John Kelly (J)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland.

Colm McDonald (C)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland.

Gary Donohoe (G)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland.

Dara M Cannon (DM)

Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Ireland, Galway, H91TK33, Ireland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Childhood trauma is associated with altered...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › Childhood trauma is associated with altered...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Childhood trauma is associated with altered...
questionsmedicales.fr › Sciences sociales › Sociologie › Facteurs sociologiques › Expériences défavorables de l'enfance › Childhood trauma is associated with altered...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Imagerie par tenseur de diffusion › Childhood trauma is associated with altered...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Imagerie par résonance magnétique de diffusion › Childhood trauma is associated with altered...