The Molecular Composition of Peptide Toxins in the Venom of Spider
Lycosa coelestis
cDNA library
diversity
peptide toxin
transcriptome sequencing
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
10 02 2023
10 02 2023
Historique:
received:
08
01
2023
revised:
02
02
2023
accepted:
08
02
2023
entrez:
24
2
2023
pubmed:
25
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
In the so-called "struggle for existence" competition, the venomous animals developed a smart and effective strategy, envenomation, for predation and defense. Biochemical analysis revealed that animal venoms are chemical pools of proteinase, peptide toxins, and small organic molecules with various biological activities. Of them, peptide toxins are of great molecular diversity and possess the capacity to modulate the activity of ion channels, the second largest group of drug targets expressed on the cell membrane, which makes them a rich resource for developing peptide drug pioneers. The spider
Identifiants
pubmed: 36828457
pii: toxins15020143
doi: 10.3390/toxins15020143
pmc: PMC9959208
pii:
doi:
Substances chimiques
Peptides
0
Spider Venoms
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Toxicon. 1998 Nov;36(11):1573-83
pubmed: 9792173
Toxins (Basel). 2019 Mar 19;11(3):
pubmed: 30893800
Drug Discov Today. 2006 Mar;11(5-6):245-53
pubmed: 16580601
Toxicon. 2003 Jun;41(7):755-63
pubmed: 12782075
PLoS One. 2013;8(1):e53343
pubmed: 23308198
J Mass Spectrom. 2008 Mar;43(3):279-95
pubmed: 18302316
Nat Protoc. 2013 Aug;8(8):1494-512
pubmed: 23845962
Pain. 2015 Jul;156(7):1247-1264
pubmed: 25782368
Toxicon. 2012 Sep 15;60(4):478-91
pubmed: 22543187
Expert Opin Biol Ther. 2011 Nov;11(11):1469-84
pubmed: 21939428
Toxins (Basel). 2016 Apr 13;8(4):110
pubmed: 27089366
Front Mol Biosci. 2022 Feb 07;9:811365
pubmed: 35198603
Bioinformatics. 2007 Nov 1;23(21):2947-8
pubmed: 17846036
FASEB J. 2017 Jul;31(7):3167-3178
pubmed: 28400471
Toxins (Basel). 2014 Mar 05;6(3):988-1001
pubmed: 24603666
Toxins (Basel). 2010 Dec;2(12):2851-71
pubmed: 22069579
Toxins (Basel). 2017 Nov 16;9(11):
pubmed: 29144441
Sci Rep. 2021 Feb 5;11(1):3211
pubmed: 33547373
J Proteome Res. 2010 May 7;9(5):2550-64
pubmed: 20192277
Peptides. 2014 Apr;54:9-18
pubmed: 24418069
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Toxins (Basel). 2012 Mar;4(3):191-227
pubmed: 22741062
Methods Enzymol. 2021;654:203-224
pubmed: 34120714
Trends Ecol Evol. 2013 Apr;28(4):219-29
pubmed: 23219381
Toxicon. 2008 Aug 1;52(2):264-76
pubmed: 18619481
Toxins (Basel). 2020 Mar 25;12(4):
pubmed: 32218140
Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11847-E11856
pubmed: 30478045
EMBO J. 2001 May 15;20(10):2349-56
pubmed: 11350923
Expert Opin Ther Targets. 2017 Jul;21(7):695-703
pubmed: 28480765
Toxicon. 2013 Apr;65:68-75
pubmed: 23391637
Proteins. 2005 Apr 1;59(1):131-40
pubmed: 15688451
Protein Sci. 2002 Feb;11(2):245-52
pubmed: 11790834
J Proteomics. 2014 Jun 13;105:217-31
pubmed: 24456813
Biochimie. 2000 Sep-Oct;82(9-10):893-907
pubmed: 11086219
Nat Rev Drug Discov. 2003 Oct;2(10):790-802
pubmed: 14526382
Toxicology. 2005 Feb 1;207(1):129-36
pubmed: 15590128
Sci Rep. 2015 Mar 18;5:9241
pubmed: 25784299
Toxicon. 2017 Jan;125:44-49
pubmed: 27867092
Toxicon. 2014 Sep;87:104-12
pubmed: 24930961
Mol Biotechnol. 1995 Jun;3(3):221-4
pubmed: 7552691
PLoS One. 2013 Jul 22;8(7):e66279
pubmed: 23894279
J Biol Chem. 2010 Apr 30;285(18):13315-20
pubmed: 20189991
Protein Sci. 1994 Oct;3(10):1833-9
pubmed: 7849598
Zoology (Jena). 2010 Jan;113(1):10-8
pubmed: 19875276