Mitochondria-targeted combination treatment strategy counteracts myocardial reperfusion injury of aged rats by modulating autophagy and inflammatory response.
Aging
Autophagy
Inflammation
Myocardial infarction
Reperfusion injury.
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
20
12
2022
accepted:
01
02
2023
medline:
1
5
2023
pubmed:
25
2
2023
entrez:
24
2
2023
Statut:
ppublish
Résumé
Aging, as a recognized risk factor for ischemic heart disease, interferes with protective mechanisms and abolishes the optimal effectiveness of cardioprotective interventions, leading to the loss of cardioprotection following myocardial ischemia/reperfusion (I/R) injury. This study was designed to explore the possible interaction of aging with cardioprotection induced by combination therapy with coenzyme Q Male Wistar rats (n = 72, 400-450 g, 22-24 months old) were randomized into groups with/without I/R and/or CoQ Co-application of CoQ We found that combination of CoQ
Sections du résumé
BACKGROUND
BACKGROUND
Aging, as a recognized risk factor for ischemic heart disease, interferes with protective mechanisms and abolishes the optimal effectiveness of cardioprotective interventions, leading to the loss of cardioprotection following myocardial ischemia/reperfusion (I/R) injury. This study was designed to explore the possible interaction of aging with cardioprotection induced by combination therapy with coenzyme Q
METHODS
METHODS
Male Wistar rats (n = 72, 400-450 g, 22-24 months old) were randomized into groups with/without I/R and/or CoQ
RESULTS
RESULTS
Co-application of CoQ
CONCLUSION
CONCLUSIONS
We found that combination of CoQ
Identifiants
pubmed: 36829080
doi: 10.1007/s11033-023-08318-3
pii: 10.1007/s11033-023-08318-3
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3973-3983Subventions
Organisme : Iran National Science Foundation (INSF)
ID : NO. 4002717
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
Références
He J et al (2022) Myocardial ischemia/reperfusion injury: mechanisms of injury and implications for management. Experimental and therapeutic medicine 23(6):1–11
doi: 10.3892/etm.2022.11357
Saeid F et al (2018) Signaling mediators modulated by cardioprotective interventions in healthy and diabetic myocardium with ischaemia–reperfusion injury. Eur J Prev Cardiol 25(14):1463–1481
doi: 10.1177/2047487318756420
pubmed: 29442529
Bai M et al (2023) Insights into research on myocardial ischemia/reperfusion injury from 2012 to 2021: a bibliometric analysis. Eur J Med Res 28(1):1–16
doi: 10.1186/s40001-022-00967-7
Khan MA et al (2020) Global epidemiology of ischemic heart disease: results from the global burden of disease study. Cureus, 12(7)
Hosseini L et al (2019) Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditions. Biogerontology 20:381–395
doi: 10.1007/s10522-019-09805-6
pubmed: 30838484
Dong M et al (2020) Aging attenuates cardiac contractility and affects therapeutic consequences for myocardial infarction. Aging and disease 11(2):365
doi: 10.14336/AD.2019.0522
pubmed: 32257547
pmcid: 7069457
Ferdinandy P et al (2014) Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning. Pharmacol Rev 66(4):1142–1174
doi: 10.1124/pr.113.008300
pubmed: 25261534
Li Y et al (2020) CARD9 promotes autophagy in cardiomyocytes in myocardial ischemia/reperfusion injury via interacting with Rubicon directly. Basic Res Cardiol 115(3):1–17
doi: 10.1007/s00395-020-0790-6
Mokhtari B, Badalzadeh R (2021) The potentials of distinct functions of autophagy to be targeted for attenuation of myocardial ischemia/reperfusion injury in preclinical studies: an up-to-date review. J Physiol Biochem 77(3):377–404
doi: 10.1007/s13105-021-00824-x
pubmed: 34173955
Du J, Li Y, Zhao W (2020) Autophagy and myocardial ischemia. Autophagy: Biology and Diseases, : p. 217–222
Ma S et al (2015) The role of the autophagy in myocardial ischemia/reperfusion injury. Biochimica et Biophysica Acta (BBA)-Molecular basis of Disease. 1852:271–2762
Wohlgemuth SE, Calvani R, Marzetti E (2014) The interplay between autophagy and mitochondrial dysfunction in oxidative stress-induced cardiac aging and pathology. J Mol Cell Cardiol 71:62–70
doi: 10.1016/j.yjmcc.2014.03.007
pubmed: 24650874
Miyamoto S (2019) Autophagy and cardiac aging. Cell Death & Differentiation 26(4):653–664
doi: 10.1038/s41418-019-0286-9
Deretic V, Klionsky DJ (2018) Autophagy and inflammation: a special review issue. Autophagy 14(2):179–180
doi: 10.1080/15548627.2017.1412229
pubmed: 29304718
pmcid: 5902244
Sarkar D, Fisher PB (2006) Molecular mechanisms of aging-associated inflammation. Cancer Lett 236(1):13–23
doi: 10.1016/j.canlet.2005.04.009
pubmed: 15978720
Awad K, Sayed A, Banach M (2022) Coenzyme Q10 reduces infarct size in Animal Models of Myocardial Ischemia-Reperfusion Injury: a Meta-analysis and Summary of underlying mechanisms. Frontiers in cardiovascular medicine, 9
Gutierrez-Mariscal FM et al (2021) Coenzyme q10 and cardiovascular diseases. Antioxidants 10(6):906
doi: 10.3390/antiox10060906
pubmed: 34205085
pmcid: 8229886
Cirilli I et al (2021) Role of coenzyme Q10 in health and disease: an update on the last 10 years (2010–2020). Antioxidants 10(8):1325
doi: 10.3390/antiox10081325
pubmed: 34439573
pmcid: 8389239
Eleawa SM et al (2015) Coenzyme Q10 protects against acute consequences of experimental myocardial infarction in rats. Int J Physiol pathophysiology Pharmacol 7(1):1
Mokhtari B et al (2022) Alpha-lipoic acid preconditioning plus ischemic postconditioning provides additional protection against myocardial reperfusion injury of diabetic rats: modulation of autophagy and mitochondrial function. Mol Biol Rep 49(3):1773–1782
doi: 10.1007/s11033-021-06987-6
pubmed: 35098396
Gholami S, Mokhtari B, Badalzadeh R (2022) Alpha-lipoic acid potentiates the anti-arrhythmic effects of ischemic postconditioning in the setting of cardiac ischemia/reperfusion injury in diabetic rats. Journal of Diabetes & Metabolic Disorders, : p.1–10
Bayrami G et al (2018) Combination of vildagliptin and ischemic postconditioning in diabetic hearts as a working strategy to reduce myocardial reperfusion injury by restoring mitochondrial function and autophagic activity. Adv Pharm Bull 8(2):319
doi: 10.15171/apb.2018.037
pubmed: 30023334
pmcid: 6046419
McCully JD et al (2017) Mitochondrial transplantation: from animal models to clinical use in humans. Mitochondrion 34:127–134
doi: 10.1016/j.mito.2017.03.004
pubmed: 28342934
Roushandeh AM, Kuwahara Y, Roudkenar MH (2019) Mitochondrial transplantation as a potential and novel master key for treatment of various incurable diseases. Cytotechnology 71(2):647–663
doi: 10.1007/s10616-019-00302-9
pubmed: 30706303
pmcid: 6465382
Bugger H, Pfeil K (2020) Mitochondrial ROS in myocardial ischemia reperfusion and remodeling. Biochimica et Biophysica Acta (BBA)-Molecular basis of Disease. 1866:1657687
Chen Q et al (2020) Endoplasmic reticulum stress-mediated mitochondrial dysfunction in aged hearts. Biochimica et Biophysica Acta (BBA)-Molecular basis of Disease. 1866:16589911
Doulamis IP et al (2020) Mitochondrial transplantation for myocardial protection in diabetic hearts. Eur J Cardiothorac Surg 57(5):836–845
doi: 10.1093/ejcts/ezz326
pubmed: 31782771
Jabbari H et al (2020) Mitochondrial transplantation ameliorates ischemia/reperfusion-induced kidney injury in rat. Biochimica et Biophysica Acta (BBA)-Molecular basis of Disease. 1866:1658098
Yan C et al (2020) Mitochondrial transplantation attenuates brain dysfunction in sepsis by driving microglial M2 polarization. Mol Neurobiol 57(9):3875–3890
doi: 10.1007/s12035-020-01994-3
pubmed: 32613465
Mokhtari B et al (2020) Human amniotic membrane mesenchymal stem cells-conditioned medium attenuates myocardial ischemia-reperfusion injury in rats by targeting oxidative stress. Iran J Basic Med Sci 23(11):1453
pubmed: 33235703
pmcid: 7671430
Mokhtari B, Badalzadeh R, Aboutaleb N (2021) Modulation of autophagy as the target of mesenchymal stem cells-derived conditioned medium in rat model of myocardial ischemia/reperfusion injury. Mol Biol Rep 48(4):3337–3348
doi: 10.1007/s11033-021-06359-0
pubmed: 33895973
Quan Y et al (2020) Mitochondrial ROS-modulated mtDNA: a potential target for cardiac aging. Oxidative medicine and cellular longevity, 2020
Haar L et al (2014) Acute consumption of a high-fat diet prior to ischemia-reperfusion results in cardioprotection through NF-κB-dependent regulation of autophagic pathways. Am J Physiol Heart Circ Physiol 307(12):H1705–H1713
doi: 10.1152/ajpheart.00271.2014
pubmed: 25239807
pmcid: 5504404
Hamacher-Brady A et al (2007) Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell Death & Differentiation 14(1):146–157
doi: 10.1038/sj.cdd.4401936
Kim I, Rodriguez-Enriquez S, Lemasters JJ (2007) Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys 462(2):245–253
doi: 10.1016/j.abb.2007.03.034
pubmed: 17475204
pmcid: 2756107
McCully JD, Pedro J, Emani SM (2022) Mitochondrial transplantation for organ rescue. Mitochondrion 64:27–33
doi: 10.1016/j.mito.2022.02.007
pubmed: 35217248
Bai Y et al (2022) Mitochondrial quality control in cardiac ischemia/reperfusion injury: new insights into mechanisms and implications. Cell Biology and Toxicology, : p.1–19
Khan NA et al (2017) Cardioprotective effect of coenzyme Q10 on apoptotic myocardial cell death by regulation of bcl-2 gene expression. J Pharmacol Pharmacotherapeutics 8(3):122–127
Liang S, Ping Z, Ge J (2017) Coenzyme Q10 regulates antioxidative stress and autophagy in acute myocardial ischemia-reperfusion injury. Oxidative Medicine and Cellular Longevity, 2017
Shin B et al (2017) Mitochondrial transplantation in myocardial ischemia and reperfusion injury.Mitochondrial Dynamics in Cardiovascular Medicine, : p.595–619
McCully JD et al (2009) Injection of isolated mitochondria during early reperfusion for cardioprotection. Am J Physiol Heart Circ Physiol 296(1):H94–H105
doi: 10.1152/ajpheart.00567.2008
pubmed: 18978192