Depletion and activation of microglia impact metabolic connectivity of the mouse brain.
FDG–PET
Metabolic connectivity
Microglia
Neurodegeneration
scRadiotracing
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
24 Feb 2023
24 Feb 2023
Historique:
received:
03
07
2022
accepted:
13
02
2023
entrez:
24
2
2023
pubmed:
25
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
We aimed to investigate the impact of microglial activity and microglial FDG uptake on metabolic connectivity, since microglial activation states determine FDG-PET alterations. Metabolic connectivity refers to a concept of interacting metabolic brain regions and receives growing interest in approaching complex cerebral metabolic networks in neurodegenerative diseases. However, underlying sources of metabolic connectivity remain to be elucidated. We analyzed metabolic networks measured by interregional correlation coefficients (ICCs) of FDG-PET scans in WT mice and in mice with mutations in progranulin (Grn) or triggering receptor expressed on myeloid cells 2 (Trem2) knockouts ( Microglia depletion by CSF1R inhibition resulted in a strong decrease of metabolic connectivity defined by decrease of mean cortical ICCs in WT mice at both ages studied (6-7 m; p = 0.0148, 9-10 m; p = 0.0191), when compared to vehicle-treated age-matched WT mice. Grn Presence, absence, and activation of microglia have a strong impact on metabolic connectivity of the mouse brain. Enhanced metabolic connectivity is associated with increased microglial FDG allocation.
Identifiants
pubmed: 36829182
doi: 10.1186/s12974-023-02735-8
pii: 10.1186/s12974-023-02735-8
pmc: PMC9951492
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Progranulins
0
Trem2 protein, mouse
0
Membrane Glycoproteins
0
Receptors, Immunologic
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
47Subventions
Organisme : Alzheimer Forschung Initiative e.V.
ID : 18014
Organisme : Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy
ID : 390857198
Organisme : Koselleck Project
ID : HA1737/16-1
Informations de copyright
© 2023. The Author(s).
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