Development of a Point-of-Care SPR Sensor for the Diagnosis of Acute Myocardial Infarction.
SPR
cTnI
epitope-imprinting
myocardial infarction
nanoMIPs
point-of-care sensor
Journal
Biosensors
ISSN: 2079-6374
Titre abrégé: Biosensors (Basel)
Pays: Switzerland
ID NLM: 101609191
Informations de publication
Date de publication:
05 Feb 2023
05 Feb 2023
Historique:
received:
10
12
2022
revised:
23
01
2023
accepted:
29
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
A novel point-of-care surface plasmon resonance (SPR) sensor was developed for the sensitive and real-time detection of cardiac troponin I (cTnI) using epitope-imprinted molecular receptors. The surface coverage of a nano-molecularly imprinted polymer (nanoMIP)-functionalized SPR sensor chip and the size of nanoMIPs (155.7 nm) were characterized using fluorescence microscopy and dynamic light scattering techniques, respectively. Atomic force microscopy, electrochemical impedance spectroscopy, square wave voltammetry and cyclic voltammetry techniques confirmed the successful implementation of each step of the sensor fabrication. The SPR bio-detection assay was initially established by targeting the cTnI peptide template, and the sensor allowed the detection of the peptide in the concentration range of 100-1000 nM with a correlation coefficient (R
Identifiants
pubmed: 36831995
pii: bios13020229
doi: 10.3390/bios13020229
pmc: PMC9953663
pii:
doi:
Substances chimiques
Molecularly Imprinted Polymers
0
Troponin I
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 428780268
Organisme : Aventis Foundation
ID : 80304368
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