Sphingoid Bases Regulate the Sigma-1 Receptor-Sphingosine and
N,N’-dimethylsphingosine
ceramide
endogenous agonists
modified native gel approach
molecular docking
sigma-1 receptor
sphingosine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Feb 2023
04 Feb 2023
Historique:
received:
31
12
2022
revised:
28
01
2023
accepted:
01
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Both bioactive sphingolipids and Sigma-1 receptor (S1R) chaperones occur ubiquitously in mammalian cell membranes. Endogenous compounds that regulate the S1R are important for controlling S1R responses to cellular stress. Herein, we interrogated the S1R in intact Retinal Pigment Epithelial cells (ARPE-19) with the bioactive sphingoid base, sphingosine (SPH), or the pain-provoking dimethylated SPH derivative,
Identifiants
pubmed: 36834510
pii: ijms24043103
doi: 10.3390/ijms24043103
pmc: PMC9962145
pii:
doi:
Substances chimiques
Sphingosine
NGZ37HRE42
Sphingolipids
0
Receptors, sigma
0
Ceramides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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