A Stability-Indicating Assay for Tetrahydrocurcumin-Diglutaric Acid and Its Applications to Evaluate Bioaccessibility in an In Vitro Digestive Model.
UHPLC
bioaccessibility
stability indicating assay
tetrahydrocurcumin (THC)
tetrahydrocurcumin diglutaric acid (TDG)
validation
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
09 Feb 2023
09 Feb 2023
Historique:
received:
29
11
2022
revised:
31
01
2023
accepted:
07
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
A simple and reliable ultra-high-performance liquid chromatographic (UHPLC) method was developed and validated for determination of tetrahydrocurcumin diglutaric acid (TDG) and applied for evaluation of its bioaccessibility. The analytical method was validated to demonstrate as a stability-indicating assay (SIA) according to the ICH Q2(R1) guidelines under various force degradation conditions including thermal degradation, moisture, acid and base hydrolysis, oxidation, and photolysis. The developed chromatographic condition could completely separate all degradants from the analyte of interest. The method linearity was verified in the range of 0.4-12 μg/mL with the coefficient of determination (r
Identifiants
pubmed: 36838664
pii: molecules28041678
doi: 10.3390/molecules28041678
pmc: PMC9966976
pii:
doi:
Substances chimiques
tetrahydrocurcumin
00U0645U03
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Chulalongkorn University
ID : HEA663300006
Organisme : Chulalongkorn University
ID : GCE 6503433003-1
Organisme : Chulalongkorn University
ID : GCUGR1125642014M
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