Licochalcone A Inhibits Prostaglandin E

Rats Animals Mitogen-Activated Protein Kinases / metabolism Microglia Lipopolysaccharides / pharmacology Cyclooxygenase 2 / metabolism Dinoprostone / metabolism Anti-Inflammatory Agents / pharmacology NF-kappa B / metabolism
8-iso-PGF2α COX-2 Glycyrrhiza glabra Licochalcone A PGE2 arachidonic acid flavonoids neuroinflammation oxidative stress

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
17 Feb 2023
Historique:
received: 31 12 2022
revised: 13 02 2023
accepted: 15 02 2023
entrez: 25 2 2023
pubmed: 26 2 2023
medline: 3 3 2023
Statut: epublish

Résumé

Neuroinflammation and oxidative stress are conditions leading to neurological and neuropsychiatric disorders. Natural compounds exerting anti-inflammatory and anti-oxidative effects, such as Licochalcone A, a bioactive flavonoid present in a traditional Chinese herb (licorice), might be beneficial for the treatment of those disorders. Therefore, this study aimed to investigate the anti-inflammatory and anti-oxidative effects of Licochalcone A in LPS-activated primary rat microglia. Licochalcone A dose-dependently prevented LPS-induced PGE

Identifiants

DOI: 10.3390/molecules28041927 PMID: 36838914 PMC: PMC9965579
pubmed: 36838914
pii: molecules28041927
doi: 10.3390/molecules28041927
pmc: PMC9965579
pii:
doi:

Substances chimiques

Mitogen-Activated Protein Kinases EC 2.7.11.24
licochalcone A JTV5467968
Lipopolysaccharides 0
Cyclooxygenase 2 EC 1.14.99.1
Dinoprostone K7Q1JQR04M
Anti-Inflammatory Agents 0
NF-kappa B 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Alzheimer Forschung Initiative
ID : 13852, 10812

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Auteurs

Harsharan Singh Bhatia (HS)

Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, D-79104 Freiburg, Germany.
Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilian University of Munich (LMU), 81377 Munich, Germany.

Matthias Apweiler (M)

Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, D-79104 Freiburg, Germany.

Lu Sun (L)

Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, D-79104 Freiburg, Germany.

Julian Baron (J)

Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, D-79104 Freiburg, Germany.

Ashwini Tirkey (A)

Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, D-79104 Freiburg, Germany.

Bernd L Fiebich (BL)

Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, D-79104 Freiburg, Germany.
ORCID: 0000-0002-9261-6771

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Licochalcone A Inhibits Prostaglandin E
questionsmedicales.fr › Eucaryotes › Animaux › Licochalcone A Inhibits Prostaglandin E
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Licochalcone A Inhibits Prostaglandin E
questionsmedicales.fr › Cellules › Névroglie › Microglie › Licochalcone A Inhibits Prostaglandin E
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Licochalcone A Inhibits Prostaglandin E
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Cyclooxygenase 2 › Licochalcone A Inhibits Prostaglandin E
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines E › Dinoprostone › Licochalcone A Inhibits Prostaglandin E
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Licochalcone A Inhibits Prostaglandin E
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Licochalcone A Inhibits Prostaglandin E