A real-life pilot study of the clinical application of pharmacogenomics testing on saliva in epilepsy.
antiseizure medications
epilepsy
pharmacogenomics
precision medicine
Journal
Epilepsia open
ISSN: 2470-9239
Titre abrégé: Epilepsia Open
Pays: United States
ID NLM: 101692036
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
14
09
2022
accepted:
22
02
2023
medline:
5
9
2023
pubmed:
26
2
2023
entrez:
25
2
2023
Statut:
ppublish
Résumé
Response to antiseizure medications (ASMs) can be influenced by several gene polymorphisms, causing either lower efficacy or higher occurrence of adverse drug reactions (ADRs). We investigated the clinical utility of salivary pharmacogenomic testing on epilepsy patients. A commercialized pharmacogenomic salivary test was performed in a cohort of epileptic patients. Genetic variants on five genes (i.e., CYP1A2, CYP2C9, CYP2C19, EPHX1, and ABCB1) involved in common ASMs metabolism were selected. Twenty-one individuals (median age [Q
Identifiants
pubmed: 36840436
doi: 10.1002/epi4.12717
pmc: PMC10472391
doi:
Substances chimiques
Anticonvulsants
0
Cytochrome P-450 CYP1A2
EC 1.14.14.1
Cytochrome P-450 CYP2C19
EC 1.14.14.1
Cytochrome P-450 CYP2C9
EC 1.14.13.-
Phenytoin
6158TKW0C5
Clobazam
2MRO291B4U
Phenobarbital
YQE403BP4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1142-1150Informations de copyright
© 2023 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.
Références
Ther Drug Monit. 2002 Dec;24(6):737-41
pubmed: 12451290
Pharmacogenomics. 2021 Mar;22(4):225-234
pubmed: 33666520
Epilepsy Res. 2013 Dec;107(3):231-7
pubmed: 24125961
Int J Mol Sci. 2021 Oct 28;22(21):
pubmed: 34769124
Epilepsia. 2017 Apr;58(4):512-521
pubmed: 28276062
Pharmacol Res. 2016 May;107:426-429
pubmed: 27080588
Curr Pediatr Rev. 2016;12(1):48-54
pubmed: 26496779
Drug Metab Dispos. 2021 Oct;49(10):882-891
pubmed: 34330718
Drug Metab Pharmacokinet. 2014;29(5):394-9
pubmed: 24717838
Epilepsy Res. 2005 Jul;65(3):185-8
pubmed: 16084694
Epileptic Disord. 2014 Dec;16(4):409-31
pubmed: 25515681
Eur J Hosp Pharm. 2022 Jul;29(4):198-201
pubmed: 32868386
Expert Opin Investig Drugs. 2009 Dec;18(12):1875-84
pubmed: 19938901
Pharmacogenetics. 2002 Apr;12(3):251-63
pubmed: 11927841
Expert Opin Drug Metab Toxicol. 2015;11(8):1269-79
pubmed: 26037375
Br J Clin Pharmacol. 2010 Mar;69(3):222-30
pubmed: 20233192
Epilepsia. 2022 Nov;63(11):2958-2969
pubmed: 36039802
Epilepsia. 2009 Jan;50(1):1-23
pubmed: 18627414
Br J Clin Pharmacol. 1999 Apr;47(4):445-9
pubmed: 10233211
Epilepsy Behav. 2011 Sep;22(1):3-8
pubmed: 21420909
N Engl J Med. 2003 Apr 10;348(15):1442-8
pubmed: 12686700
Epilepsia Open. 2023 Sep;8(3):1142-1150
pubmed: 36840436
BMJ Open. 2015 Jun 01;5(6):e008298
pubmed: 26033949
Curr Neuropharmacol. 2019;17(1):99-106
pubmed: 29119932
J Mol Diagn. 2022 Mar;24(3):253-261
pubmed: 35041929
Int J Clin Pharmacol Ther. 2015 Jul;53(7):504-16
pubmed: 25943175