Constitutive and induced forms of membrane-bound proteinase 3 interact with antineutrophil cytoplasmic antibodies and promote immune activation of neutrophils.

Animals Humans Mice Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / metabolism Antibodies, Antineutrophil Cytoplasmic Myeloblastin / immunology Neutrophils / metabolism Protease Inhibitors / metabolism Superoxides / metabolism
PR3-ANCA alpha-1 protease inhibitor anti-PR3 mAbs autoantibody immune activation inflammation neutrophil proteinase 3 therapeutic strategy vasculitis

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
04 2023
Historique:
received: 03 07 2022
revised: 21 02 2023
accepted: 23 02 2023
medline: 28 4 2023
pubmed: 28 2 2023
entrez: 27 2 2023
Statut: ppublish

Résumé

Proteinase 3 (PR3) is the main target antigen of antineutrophil cytoplasmic antibodies (ANCAs) in PR3-ANCA-associated vasculitis. A small fraction of PR3 is constitutively exposed on the surface of quiescent blood neutrophils in a proteolytically inactive form. When activated, neutrophils expose an induced form of membrane-bound PR3 (PR3

Identifiants

DOI: 10.1016/j.jbc.2023.103072 PMID: 36849007 PMC: PMC10124916
pubmed: 36849007
pii: S0021-9258(23)00204-1
doi: 10.1016/j.jbc.2023.103072
pmc: PMC10124916
pii:
doi:

Substances chimiques

Antibodies, Antineutrophil Cytoplasmic 0
Myeloblastin EC 3.4.21.76
Protease Inhibitors 0
Superoxides 11062-77-4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103072

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.

Auteurs

INSERM UMR-1100, "Research Center for Respiratory Diseases" and University of Tours, Tours, France.

Seda Seren (S)

INSERM UMR-1100, "Research Center for Respiratory Diseases" and University of Tours, Tours, France.

Roxane Lemoine (R)

EA4245 "Transplantation, Immunology and Inflammation", University of Tours, France and Clinical Immunology and Allergology Service, Tours University Hospital, Tours, France.

Amber M Hummel (AM)

Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA.

Jean-Edouard Margotin (JE)

INSERM UMR-1100, "Research Center for Respiratory Diseases" and University of Tours, Tours, France.

Jamel El-Benna (J)

Université de Paris, INSERM UMR-1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation (CRI), Laboratoire d'Excellence Inflamex, Faculté de Médecine Xavier Bichat, Paris, France.

Cyrille Hoarau (C)

EA4245 "Transplantation, Immunology and Inflammation", University of Tours, France and Clinical Immunology and Allergology Service, Tours University Hospital, Tours, France.

Ulrich Specks (U)

Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA.

Dieter E Jenne (DE)

Comprehensive Pneumology Center, Institute of Lung Biology and Disease, German Center for Lung Research (DZL), 81377 Munich and Max Planck Institute of Neurobiology, Planegg-Martinsried, Germany.

Brice Korkmaz (B)

INSERM UMR-1100, "Research Center for Respiratory Diseases" and University of Tours, Tours, France. Electronic address: brice.korkmaz@inserm.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Constitutive and induced forms of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Constitutive and induced forms of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Constitutive and induced forms of...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Vascularites associées aux anticorps anti-cytoplasme des neutrophiles › Constitutive and induced forms of...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Anticorps anti-cytoplasme des polynucléaires neutrophiles › Constitutive and induced forms of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Myéloblastine › Constitutive and induced forms of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Constitutive and induced forms of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases › Constitutive and induced forms of...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Superoxydes › Constitutive and induced forms of...