Pyroptosis in platelets: Thrombocytopenia and inflammation.
GSDMD
NLRP3
caspase-1
inflammasome
platelets
pyroptosis
Journal
Journal of clinical laboratory analysis
ISSN: 1098-2825
Titre abrégé: J Clin Lab Anal
Pays: United States
ID NLM: 8801384
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
revised:
28
12
2022
received:
17
05
2022
accepted:
05
02
2023
pubmed:
1
3
2023
medline:
22
3
2023
entrez:
28
2
2023
Statut:
ppublish
Résumé
The purpose of this manuscript was to conclude the role of platelets in immune inflammation and discuss the complex mechanisms of pyroptosis in platelets as well as their related diseases. This article reviewed the existing literature to see the development of pyroptosis in platelets. Platelets have been shown to be capable of activating inflammasomes assembled from NOD-like receptor family pyrin domain containing 3 (NLRP3), apoptosis-associated speck-like protein containing a CARD (ASC) and caspase-1. Recently, they were also implicated in pyroptosis. Cleaved by caspase-1, N-terminal gasdermin D (N-GSDMD) could form pores in the cell membrane, inducing nonselective intracellular substance release. This programmed cell death induced thrombocytopenia and inflammatory cytokine release such as IL-1β and IL-18, promoting platelet aggregation, vaso-occlusion, endothelial permeability and cascaded inflammatory response. Pyroptosis in platelets contributes to thrombocytopenia and inflammation.
Identifiants
pubmed: 36852778
doi: 10.1002/jcla.24852
pmc: PMC10020847
doi:
Substances chimiques
NLR Family, Pyrin Domain-Containing 3 Protein
0
Caspase 1
EC 3.4.22.36
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e24852Subventions
Organisme : National Natural Science Foundation of China
ID : 82072352
Organisme : Natural Science Foundation of Beijing Municipality
ID : 7192222
Informations de copyright
© 2023 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.
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