Modulating Lysosomal pH through Innovative Multimerized Succinic Acid-Based Nucleolipid Derivatives.


Journal

Bioconjugate chemistry
ISSN: 1520-4812
Titre abrégé: Bioconjug Chem
Pays: United States
ID NLM: 9010319

Informations de publication

Date de publication:
15 03 2023
Historique:
pubmed: 1 3 2023
medline: 17 3 2023
entrez: 28 2 2023
Statut: ppublish

Résumé

The multimerization of active compounds has emerged as a successful approach, mainly to address the multivalency of numerous biological targets. Regarding the pharmaceutical prospect, carrying several active ingredient units on the same synthetic scaffold was a practical approach to enhance drug delivery or biological activity with a lower global concentration. Various examples have highlighted better

Identifiants

pubmed: 36853958
doi: 10.1021/acs.bioconjchem.3c00041
doi:

Substances chimiques

Succinic Acid AB6MNQ6J6L
Prodrugs 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

572-580

Auteurs

Mathias Brouillard (M)

University of Bordeaux, INSERM U1212, UMR CNRS 5320, Bordeaux 33405, France.

Rémi Kinet (R)

Univ. de Bordeaux, CNRS, IMN, UMR 5293, Bordeaux F-33000, France.

Marie Joyeux (M)

University of Bordeaux, INSERM U1212, UMR CNRS 5320, Bordeaux 33405, France.

Benjamin Dehay (B)

Univ. de Bordeaux, CNRS, IMN, UMR 5293, Bordeaux F-33000, France.

Sylvie Crauste-Manciet (S)

University of Bordeaux, INSERM U1212, UMR CNRS 5320, Bordeaux 33405, France.
Univ. Angers, CHU Angers, INSERM, CNRS, MINT, SFR ICAT, F-49000 Angers, France.

Valérie Desvergnes (V)

University of Bordeaux, INSERM U1212, UMR CNRS 5320, Bordeaux 33405, France.

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Classifications MeSH