Modulating Lysosomal pH through Innovative Multimerized Succinic Acid-Based Nucleolipid Derivatives.
Journal
Bioconjugate chemistry
ISSN: 1520-4812
Titre abrégé: Bioconjug Chem
Pays: United States
ID NLM: 9010319
Informations de publication
Date de publication:
15 03 2023
15 03 2023
Historique:
pubmed:
1
3
2023
medline:
17
3
2023
entrez:
28
2
2023
Statut:
ppublish
Résumé
The multimerization of active compounds has emerged as a successful approach, mainly to address the multivalency of numerous biological targets. Regarding the pharmaceutical prospect, carrying several active ingredient units on the same synthetic scaffold was a practical approach to enhance drug delivery or biological activity with a lower global concentration. Various examples have highlighted better
Identifiants
pubmed: 36853958
doi: 10.1021/acs.bioconjchem.3c00041
doi:
Substances chimiques
Succinic Acid
AB6MNQ6J6L
Prodrugs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM