Thyroid-stimulating hormone receptor signaling restores skeletal muscle stem cell regeneration in rats with muscular dystrophy.

Animals Rats Receptors, Thyrotropin Receptors, G-Protein-Coupled Muscular Dystrophy, Duchenne Muscle Fibers, Skeletal Stem Cells Regeneration Thyrotropin

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
03 2023
Historique:
entrez: 1 3 2023
pubmed: 2 3 2023
medline: 4 3 2023
Statut: ppublish

Résumé

Duchenne muscular dystrophy (DMD) is a severe and progressive myopathy leading to motor and cardiorespiratory impairment. We analyzed samples from patients with DMD and a preclinical rat model of severe DMD and determined that compromised repair capacity of muscle stem cells in DMD is associated with early and progressive muscle stem cell senescence. We also found that extraocular muscles (EOMs), which are spared by the disease in patients, contain muscle stem cells with long-lasting regenerative potential. Using single-cell transcriptomics analysis of muscles from a rat model of DMD, we identified the gene encoding thyroid-stimulating hormone receptor (

Identifiants

DOI: 10.1126/scitranslmed.add5275 PMID: 36857434
pubmed: 36857434
doi: 10.1126/scitranslmed.add5275
doi:

Substances chimiques

Receptors, Thyrotropin 0
Receptors, G-Protein-Coupled 0
Thyrotropin 9002-71-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadd5275

Auteurs

Valentina Taglietti (V)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.
ORCID: 0000-0001-8639-8088

Kaouthar Kefi (K)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.

Lea Rivera (L)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.

Oriane Bergiers (O)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.

Nastasia Cardone (N)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.
ORCID: 0000-0002-9115-718X

Fanny Coulpier (F)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.

Stamatia Gioftsidi (S)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.

Bernadette Drayton-Libotte (B)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.

Cyrielle Hou (C)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.
ORCID: 0000-0002-0258-4738

François-Jérôme Authier (FJ)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.
AP-HP, Hôpital Mondor, FHU SENEC, Service d'histologie, F-94010 Créteil, France.
ORCID: 0000-0002-0182-2052

France Pietri-Rouxel (F)

Sorbonne Université, INSERM, UMRS974, Center for Research in Myology, F-75013, Paris, France.
ORCID: 0000-0002-6258-7594

Matthieu Robert (M)

Borelli centre, UMR 9010, CNRS - SSA - ENS Paris Saclay - Université Paris Cité, F-75016, Paris, France.
Ophthalmology Department, Necker Enfants Malades University Hospital, AP-HP, F-75015, Paris, France.
ORCID: 0000-0003-3353-8117

Dominique Bremond-Gignac (D)

Ophthalmology Department, Necker Enfants Malades University Hospital, AP-HP, F-75015, Paris, France.
INSERM, UMRS1138, Team 17, Sorbonne Paris Cité University, Centre de Recherche des Cordeliers, F-75006, Paris, France.
ORCID: 0000-0002-3563-5482

Claudio Bruno (C)

Center of Translational and Experimental Myology, IRCCS Gaslini Institute, DINOGMI, University of Genova, 16147, Genova, Italy.
ORCID: 0000-0002-3426-2901

Chiara Fiorillo (C)

Center of Translational and Experimental Myology, IRCCS Gaslini Institute, DINOGMI, University of Genova, 16147, Genova, Italy.
ORCID: 0000-0001-9027-343X

Edoardo Malfatti (E)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.
AP-HP, Hôpital Mondor, FHU SENEC, Service d'histologie, F-94010 Créteil, France.

Peggy Lafuste (P)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.
ORCID: 0000-0001-8239-3482

Laurent Tiret (L)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.
École nationale vétérinaire d'Alfort, IMRB, F-94700, Maisons-Alfort, France.
ORCID: 0000-0001-8573-8335

Frédéric Relaix (F)

Univ Paris-Est Créteil, INSERM, U955 IMRB, F-94010 Créteil, France.
AP-HP, Hôpital Mondor, FHU SENEC, Service d'histologie, F-94010 Créteil, France.
École nationale vétérinaire d'Alfort, IMRB, F-94700, Maisons-Alfort, France.
EFS, IMRB, F-94010, Creteil, France.
ORCID: 0000-0003-1270-1472

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Thyroid-stimulating hormone receptor signaling...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Thyroid-stimulating hormone receptor signaling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteur TSH › Thyroid-stimulating hormone receptor signaling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Thyroid-stimulating hormone receptor signaling...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Dystrophies musculaires › Myopathie de Duchenne › Thyroid-stimulating hormone receptor signaling...
questionsmedicales.fr › Cellules › Cellules musculaires › Fibres musculaires squelettiques › Thyroid-stimulating hormone receptor signaling...
questionsmedicales.fr › Cellules › Cellules souches › Thyroid-stimulating hormone receptor signaling...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Thyroid-stimulating hormone receptor signaling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones antéhypophysaires › Thyréostimuline › Thyroid-stimulating hormone receptor signaling...