Cystathionine-β-synthase X proteins negatively regulate NADPH-thioredoxin reductase C activity.
2-Cys Prx
CBSX proteins
NTRC
Redox regulation
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
23 04 2023
23 04 2023
Historique:
received:
12
02
2023
accepted:
20
02
2023
pubmed:
2
3
2023
medline:
22
3
2023
entrez:
1
3
2023
Statut:
ppublish
Résumé
Redox regulation is a posttranslational modification based on the redox reaction of protein thiols. A small ubiquitous protein thioredoxin (Trx) plays a central role in redox regulation, but a unique redox-regulatory factor called NADPH-Trx reductase C (NTRC) is also found in plant chloroplasts and some cyanobacteria. Several important functions of NTRC have been suggested, but the mechanism for controlling NTRC activity remains undetermined. Cystathionine-β-synthase X (CBSX) proteins have been previously shown to interact with NTRC physically. Based on these observations, this study biochemically investigated the functional interaction between CBSX proteins and NTRC from Arabidopsis thaliana in vitro. Consequently, we concluded that CBSX proteins act as negative regulators of NTRC in the presence of AMP.
Identifiants
pubmed: 36857899
pii: S0006-291X(23)00235-8
doi: 10.1016/j.bbrc.2023.02.055
pii:
doi:
Substances chimiques
Antioxidants
0
Arabidopsis Proteins
0
Cystathionine
375YFJ481O
Cystathionine beta-Synthase
EC 4.2.1.22
Thioredoxin-Disulfide Reductase
EC 1.8.1.9
Thioredoxins
52500-60-4
NTRC protein, Arabidopsis
EC 1.8.1.9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
47-52Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no conflicts of interest to declare.