Molecular characterization of class 1 integrons in carbapenem-resistant Enterobacterales isolates.

Carbapenems / pharmacology Integrons / genetics Anti-Bacterial Agents / pharmacology Trimethoprim, Sulfamethoxazole Drug Combination / pharmacology Amikacin Microbial Sensitivity Tests
Carbapenem-resistant Enterobacterales Gene cassettes Integron Promoters

Journal

Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191

Informations de publication

Date de publication:
Apr 2023
Historique:
received: 26 10 2022
revised: 29 01 2023
accepted: 26 02 2023
medline: 4 4 2023
pubmed: 2 3 2023
entrez: 1 3 2023
Statut: ppublish

Résumé

Carbapenem-resistant Enterobacterales (CRE) infections result in higher treatment costs and mortality rates. Integrons play important roles in emergence and spread of antibiotic resistant genes. To get a better understand on the effects of integron on CRE resistance, distribution of common carbapenemase genes and class 1 integron in clinical CRE isolates were investigated. Carbapenemase genes, including bla Of 161 CRE isolates, the most prevalent carbapenemase gene was bla Class 1 integrons play important roles in the emergence and spread of CRE resistance. To the best of our knowledge, this is the first report of aadB-catB8-bla

Identifiants

DOI: 10.1016/j.micpath.2023.106051 PMID: 36858185
pubmed: 36858185
pii: S0882-4010(23)00084-0
doi: 10.1016/j.micpath.2023.106051
pii:
doi:

Substances chimiques

Carbapenems 0
Anti-Bacterial Agents 0
Trimethoprim, Sulfamethoxazole Drug Combination 8064-90-2
Amikacin 84319SGC3C

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106051

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflict of interest.

Auteurs

Tong Wang (T)

Department of Laboratory Medicine, Anhui University of Science and Technology Affiliated Fengxian Hospital, 6600 Nanfeng Road, Shanghai, 201499, China.

Yu Zhu (Y)

Department of Laboratory Medicine, Anhui University of Science and Technology Affiliated Fengxian Hospital, 6600 Nanfeng Road, Shanghai, 201499, China.

Wenwen Zhu (W)

Department of Laboratory Medicine, Southern Medical University Affiliated Fengxian Hospital, 6600 Nanfeng Road, Shanghai, 201499, China.

Mei Cao (M)

Department of Laboratory Medicine, Anhui University of Science and Technology Affiliated Fengxian Hospital, 6600 Nanfeng Road, Shanghai, 201499, China.

Quhao Wei (Q)

Department of Laboratory Medicine, Anhui University of Science and Technology Affiliated Fengxian Hospital, 6600 Nanfeng Road, Shanghai, 201499, China; Department of Laboratory Medicine, Southern Medical University Affiliated Fengxian Hospital, 6600 Nanfeng Road, Shanghai, 201499, China; Department of Laboratory Medicine, Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus, 6600 Nanfeng Road, Shanghai, 201499, China. Electronic address: lab_wqh@126.com.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Carbapénèmes › Molecular characterization of class 1...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Intégrons › Molecular characterization of class 1...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Molecular characterization of class 1...
questionsmedicales.fr › Préparations pharmaceutiques › Association médicamenteuse › Association triméthoprime-sulfaméthoxazole › Molecular characterization of class 1...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Kanamycine › Amikacine › Molecular characterization of class 1...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Molecular characterization of class 1...