Early life growth trajectories in cystic fibrosis are associated with lung function at age six.
BMI
Cystic fibrosis
Early childhood
FEV(1)pp
Growth trajectories
Registry
WFL
Journal
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
ISSN: 1873-5010
Titre abrégé: J Cyst Fibros
Pays: Netherlands
ID NLM: 101128966
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
08
11
2022
revised:
11
02
2023
accepted:
20
02
2023
pmc-release:
01
05
2024
medline:
12
6
2023
pubmed:
2
3
2023
entrez:
1
3
2023
Statut:
ppublish
Résumé
Higher growth percentiles are associated with more favorable lung function in cystic fibrosis (CF), prompting the creation of CF Foundation (CFF) nutritional guidelines. To describe early childhood growth trajectories within CF, to determine if growth trajectories are associated with differences in lung function at age six, and to identify factors that differ between trajectory groups. Retrospective cohort study of children diagnosed with CF and born 2000-2011 using the US CFF Patient Registry. Annualized growth parameters prior to age six were included in group-based trajectory modeling to identify unique early life growth trajectories. FEV1 percent predicted (FEV1pp) at age six was compared between trajectory groups using linear regression. Factors associated with group membership were identified using multinomial logistic regression. 6,809 children met inclusion criteria. Six discrete growth trajectories were identified, including three groups that began with growth parameters >50th percentile, termed: "always high", "gradual decliner", "rapid decliner", and three which began with growth parameters <50th percentile, termed: "rapid riser", "gradual riser", "always low". FEV1pp at age six was highest for the Always High trajectory. The Always Low trajectory was nearly 10% lower than the Always High trajectory. Sex, ethnicity, newborn screening and pancreatic function were associated with trajectory class membership. Distinct early life growth trajectories were identified within CF. Trajectories that met CFF nutritional guideline recommendations were associated with higher FEV1pp at age six. CF care teams should continue to partner with families to encourage interventions to support optimal growth to improve lung function in CF.
Sections du résumé
BACKGROUND
BACKGROUND
Higher growth percentiles are associated with more favorable lung function in cystic fibrosis (CF), prompting the creation of CF Foundation (CFF) nutritional guidelines.
OBJECTIVES
OBJECTIVE
To describe early childhood growth trajectories within CF, to determine if growth trajectories are associated with differences in lung function at age six, and to identify factors that differ between trajectory groups.
METHODS
METHODS
Retrospective cohort study of children diagnosed with CF and born 2000-2011 using the US CFF Patient Registry. Annualized growth parameters prior to age six were included in group-based trajectory modeling to identify unique early life growth trajectories. FEV1 percent predicted (FEV1pp) at age six was compared between trajectory groups using linear regression. Factors associated with group membership were identified using multinomial logistic regression.
RESULTS
RESULTS
6,809 children met inclusion criteria. Six discrete growth trajectories were identified, including three groups that began with growth parameters >50th percentile, termed: "always high", "gradual decliner", "rapid decliner", and three which began with growth parameters <50th percentile, termed: "rapid riser", "gradual riser", "always low". FEV1pp at age six was highest for the Always High trajectory. The Always Low trajectory was nearly 10% lower than the Always High trajectory. Sex, ethnicity, newborn screening and pancreatic function were associated with trajectory class membership.
CONCLUSIONS
CONCLUSIONS
Distinct early life growth trajectories were identified within CF. Trajectories that met CFF nutritional guideline recommendations were associated with higher FEV1pp at age six. CF care teams should continue to partner with families to encourage interventions to support optimal growth to improve lung function in CF.
Identifiants
pubmed: 36858852
pii: S1569-1993(23)00060-7
doi: 10.1016/j.jcf.2023.02.008
pmc: PMC10257762
mid: NIHMS1878559
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
395-401Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL128475
Pays : United States
Informations de copyright
Copyright © 2023. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest All authors disclose that they have no financial interests in the subject of this manuscript. The funding sources have no role in the analysis or drafting of the manuscript.
Références
J Cyst Fibros. 2022 Jan;21(1):104-110
pubmed: 34175244
J Pediatr Gastroenterol Nutr. 2011 Oct;53(4):453-8
pubmed: 21613963
Pediatr Pulmonol. 2004 Apr;37(4):324-9
pubmed: 15022129
J Pediatr. 2007 Aug;151(2):134-9, 139.e1
pubmed: 17643762
Annu Rev Clin Psychol. 2010;6:109-38
pubmed: 20192788
Gut. 1999 Jan;44(1):87-90
pubmed: 9862831
JAMA Pediatr. 2017 Jun 1;171(6):546-554
pubmed: 28437538
J Pediatr. 2013 Mar;162(3):530-535.e1
pubmed: 23062247
Pediatr Pulmonol. 2012 Aug;47(8):743-8
pubmed: 22298389
Thorax. 2002 Jul;57(7):596-601
pubmed: 12096202
J Pediatr. 2009 Dec;155(6 Suppl):S73-93
pubmed: 19914445
J Am Diet Assoc. 2008 May;108(5):832-9
pubmed: 18442507
J Pediatr Gastroenterol Nutr. 2002 Sep;35(3):246-59
pubmed: 12352509
Ann Am Thorac Soc. 2016 Jul;13(7):1173-9
pubmed: 27078236
Child Dev. 1999 Sep-Oct;70(5):1181-96
pubmed: 10546339
Ann Nutr Metab. 2014;65(2-3):205-10
pubmed: 25413659
J Womens Health (Larchmt). 2014 Dec;23(12):1012-20
pubmed: 25495366
Pediatrics. 2009 Feb;123(2):714-22
pubmed: 19171643
J Pediatr. 2015 Nov;167(5):1081-8.e1
pubmed: 26340874
J Acad Nutr Diet. 2021 Jul;121(7):1364-1378.e2
pubmed: 32532673
Prev Med Rep. 2019 Mar 12;14:100834
pubmed: 30976485
Pediatrics. 2016 Apr;137(4):
pubmed: 27009033
J Cyst Fibros. 2005 Sep;4(3):175-82
pubmed: 15982934
J Am Diet Assoc. 1999 Feb;99(2):191-4
pubmed: 9972186
Eur Respir J. 2012 Dec;40(6):1324-43
pubmed: 22743675
J Pediatr. 2003 Jun;142(6):624-30
pubmed: 12838189
Pediatr Pulmonol. 2017 Jul;52(7):909-915
pubmed: 28436621