Interactions of Insomnia and Sedative-Hypnotic Drug Use Associated with Frailty Over Time Among Older Adults.

Humans Aged Sleep Initiation and Maintenance Disorders / drug therapy Frailty / epidemiology Longitudinal Studies Hypnotics and Sedatives / adverse effects Sleep
Sleep disturbance benzodiazepine receptor agonist frailty

Journal

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
ISSN: 1545-7214
Titre abrégé: Am J Geriatr Psychiatry
Pays: England
ID NLM: 9309609

Informations de publication

Date de publication:
06 2023
Historique:
received: 21 11 2022
revised: 29 01 2023
accepted: 30 01 2023
medline: 9 5 2023
pubmed: 2 3 2023
entrez: 1 3 2023
Statut: ppublish

Résumé

Insomnia and frailty are prevalent in older adults. This study aimed to elucidate the impact of insomnia and sedative-hypnotic use on the frailty rate over time. We used data from community-dwelling older adults (mean ± SD age = 69.4 ± 8.2 years) from the Healthy Aging Longitudinal Study in Taiwan (HALST). A total of 4,744 participants were included in the study and were followed up for an average of 3.2 years. Frailty was assessed using the Fried criteria. Self-reported sleep problems, sedative-hypnotic use, and claims records from the National Health Insurance database were used. The generalized equation estimation (GEE) approach was applied to account for correlations between repeated measures. The average impact of insomnia and drug use on frailty over time was estimated by adjusting for potential confounding factors using the logic link in the GEE approach. The adjusted odds ratio (OR) of frailty was 1.41 (95% CI: [1.16, 1.72], Z-test statistics Z = 3.39, p <0.001) for insomnia and 1.52 ([1.16, 2.00], Z = 3.00, p = 0.0027) for sedative-hypnotic use. Interactions between insomnia and sedative-hypnotic use with frailty were not statistically significant. Long sleep duration > 8 hours, daytime sleepiness, and sleep apnea was also associated with an increased likelihood of developing frailty. Notably, a dose-response relationship between sedative-hypnotic drug use and frailty was observed. Insomnia and sedative-hypnotic use were independently associated with increased frailty. The implementation of nonpharmacological treatments to attenuate insomnia may reduce frailty rates.

Sections du résumé

BACKGROUND
Insomnia and frailty are prevalent in older adults. This study aimed to elucidate the impact of insomnia and sedative-hypnotic use on the frailty rate over time.
METHODS
We used data from community-dwelling older adults (mean ± SD age = 69.4 ± 8.2 years) from the Healthy Aging Longitudinal Study in Taiwan (HALST). A total of 4,744 participants were included in the study and were followed up for an average of 3.2 years. Frailty was assessed using the Fried criteria. Self-reported sleep problems, sedative-hypnotic use, and claims records from the National Health Insurance database were used. The generalized equation estimation (GEE) approach was applied to account for correlations between repeated measures. The average impact of insomnia and drug use on frailty over time was estimated by adjusting for potential confounding factors using the logic link in the GEE approach.
RESULTS
The adjusted odds ratio (OR) of frailty was 1.41 (95% CI: [1.16, 1.72], Z-test statistics Z = 3.39, p <0.001) for insomnia and 1.52 ([1.16, 2.00], Z = 3.00, p = 0.0027) for sedative-hypnotic use. Interactions between insomnia and sedative-hypnotic use with frailty were not statistically significant. Long sleep duration > 8 hours, daytime sleepiness, and sleep apnea was also associated with an increased likelihood of developing frailty. Notably, a dose-response relationship between sedative-hypnotic drug use and frailty was observed.
CONCLUSIONS
Insomnia and sedative-hypnotic use were independently associated with increased frailty. The implementation of nonpharmacological treatments to attenuate insomnia may reduce frailty rates.

Identifiants

DOI: 10.1016/j.jagp.2023.01.028 PMID: 36858927
pubmed: 36858927
pii: S1064-7481(23)00162-8
doi: 10.1016/j.jagp.2023.01.028
pii:
doi:

Substances chimiques

Hypnotics and Sedatives 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

438-448

Informations de copyright

Copyright © 2023 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

Auteurs

Chi-Shin Wu (CS)

National Center for Geriatrics and Welfare Research (CSW, CCH), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Psychiatry (CSW), National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan; Institute of Population Health Sciences (HYT, CYL, ICW, HYC, CCH, CAH, YFC), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Human Development and Family Studies (HYT), Colorado State University, Fort Collins, CO. Electronic address: chishinwu@nhri.edu.tw.

Han-Yun Tseng (HY)

National Center for Geriatrics and Welfare Research (CSW, CCH), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Psychiatry (CSW), National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan; Institute of Population Health Sciences (HYT, CYL, ICW, HYC, CCH, CAH, YFC), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Human Development and Family Studies (HYT), Colorado State University, Fort Collins, CO.

Chun-Yi Lee (CY)

National Center for Geriatrics and Welfare Research (CSW, CCH), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Psychiatry (CSW), National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan; Institute of Population Health Sciences (HYT, CYL, ICW, HYC, CCH, CAH, YFC), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Human Development and Family Studies (HYT), Colorado State University, Fort Collins, CO.

I-Chien Wu (IC)

National Center for Geriatrics and Welfare Research (CSW, CCH), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Psychiatry (CSW), National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan; Institute of Population Health Sciences (HYT, CYL, ICW, HYC, CCH, CAH, YFC), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Human Development and Family Studies (HYT), Colorado State University, Fort Collins, CO.

Hsing-Yi Chang (HY)

National Center for Geriatrics and Welfare Research (CSW, CCH), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Psychiatry (CSW), National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan; Institute of Population Health Sciences (HYT, CYL, ICW, HYC, CCH, CAH, YFC), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Human Development and Family Studies (HYT), Colorado State University, Fort Collins, CO.

Chih-Cheng Hsu (CC)

National Center for Geriatrics and Welfare Research (CSW, CCH), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Psychiatry (CSW), National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan; Institute of Population Health Sciences (HYT, CYL, ICW, HYC, CCH, CAH, YFC), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Human Development and Family Studies (HYT), Colorado State University, Fort Collins, CO.

Chao Agnes Hsiung (CA)

National Center for Geriatrics and Welfare Research (CSW, CCH), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Psychiatry (CSW), National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan; Institute of Population Health Sciences (HYT, CYL, ICW, HYC, CCH, CAH, YFC), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Human Development and Family Studies (HYT), Colorado State University, Fort Collins, CO.

Yen-Feng Chiu (YF)

National Center for Geriatrics and Welfare Research (CSW, CCH), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Psychiatry (CSW), National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan; Institute of Population Health Sciences (HYT, CYL, ICW, HYC, CCH, CAH, YFC), National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Human Development and Family Studies (HYT), Colorado State University, Fort Collins, CO. Electronic address: yfchiu@nhri.edu.tw.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Interactions of Insomnia and Sedative-Hypnotic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Interactions of Insomnia and Sedative-Hypnotic...
questionsmedicales.fr › Troubles mentaux › Troubles de la veille et du sommeil › Dyssomnies › Troubles du sommeil d'origine intrinsèque › Troubles de l'endormissement et du maintien du sommeil › Interactions of Insomnia and Sedative-Hypnotic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fragilité › Interactions of Insomnia and Sedative-Hypnotic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Interactions of Insomnia and Sedative-Hypnotic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Hypnotiques et sédatifs › Interactions of Insomnia and Sedative-Hypnotic...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Interactions of Insomnia and Sedative-Hypnotic...