Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation.

Sheep Animals Prion Proteins Prions Sheep, Domestic Scrapie Action Potentials

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
01 03 2023
Historique:
received: 11 07 2022
accepted: 17 02 2023
entrez: 1 3 2023
pubmed: 2 3 2023
medline: 4 3 2023
Statut: epublish

Résumé

Prion diseases are progressive neurodegenerative disorders with no effective therapeutics. The central event leading to the pathology in the diseases is the conversion of PrP

Identifiants

DOI: 10.1038/s41598-023-30202-0 PMID: 36859422 PMC: PMC9978027
pubmed: 36859422
doi: 10.1038/s41598-023-30202-0
pii: 10.1038/s41598-023-30202-0
pmc: PMC9978027
doi:

Substances chimiques

Prion Proteins 0
Prions 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3452

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/J014508/1
Pays : United Kingdom

Informations de copyright

© 2023. The Author(s).

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Auteurs

Katarzyna Kopycka (K)

School of Veterinary Medicine and Science, The University of Nottingham, College Rd., Sutton Bonington, Loughborough, LE12 5RD, Leicestershire, UK.

Ben C Maddison (BC)

ADAS Biotechnology, Unit 27, Beeston Business Park, Technology Drive, Beeston, NG9 1LA, Nottinghamshire, UK.

Kevin C Gough (KC)

School of Veterinary Medicine and Science, The University of Nottingham, College Rd., Sutton Bonington, Loughborough, LE12 5RD, Leicestershire, UK. kevin.gough@nottingham.ac.uk.
ORCID: 0000-0001-5211-2088

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Ovis › Recombinant ovine prion protein can be mutated...
questionsmedicales.fr › Eucaryotes › Animaux › Recombinant ovine prion protein can be mutated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Prions › Protéines prion › Recombinant ovine prion protein can be mutated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Prions › Recombinant ovine prion protein can be mutated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Ovis › Ovis aries › Recombinant ovine prion protein can be mutated...
questionsmedicales.fr › Maladies de l'animal › Maladies des ovins › Tremblante › Recombinant ovine prion protein can be mutated...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Recombinant ovine prion protein can be mutated...