Hyperactivity of the CD155 immune checkpoint suppresses anti-viral immunity in patients with coronary artery disease.
Journal
Nature cardiovascular research
ISSN: 2731-0590
Titre abrégé: Nat Cardiovasc Res
Pays: England
ID NLM: 9918284280206676
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
entrez:
2
3
2023
pubmed:
3
3
2023
medline:
3
3
2023
Statut:
ppublish
Résumé
Pre-existent cardiovascular disease is a risk factor for weak anti-viral immunity, but underlying mechanisms remain undefined. Here, we report that patients with coronary artery disease (CAD) have macrophages (Mϕ) that actively suppress the induction of helper T cells reactive to two viral antigens: the SARS-CoV2 Spike protein and the Epstein-Barr virus (EBV) glycoprotein 350. CAD Mϕ overexpressed the methyltransferase METTL3, promoting the accumulation of N⁶-methyladenosine (m6A) in Poliovirus receptor (CD155) mRNA. m6A modifications of positions 1635 and 3103 in the 3'UTR of CD155 mRNA stabilized the transcript and enhanced CD155 surface expression. As a result, the patients' Mϕ abundantly expressed the immunoinhibitory ligand CD155 and delivered negative signals to CD4
Identifiants
pubmed: 36860353
doi: 10.1038/s44161-022-00096-8
pmc: PMC9974158
mid: NIHMS1825134
doi:
Types de publication
Journal Article
Langues
eng
Pagination
634-648Subventions
Organisme : NIAID NIH HHS
ID : R01 AI129191
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142068
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI108906
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI108891
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL129941
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI057266
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR042527
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG045779
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117913
Pays : United States
Déclaration de conflit d'intérêts
Declaration of Interests: The authors have declared that no conflict of interest exists.
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