Unsaturated bond recognition leads to biased signal in a fatty acid receptor.

Cryoelectron Microscopy Ligands Receptors, G-Protein-Coupled / agonists Fatty Acids, Omega-3 / chemistry Humans Biphenyl Compounds / chemistry Phenylpropionates / chemistry Drug Design Protein Conformation Eicosapentaenoic Acid / chemistry Mutation, Missense Polymorphism, Single Nucleotide

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
07 04 2023
Historique:
medline: 10 4 2023
pubmed: 3 3 2023
entrez: 2 3 2023
Statut: ppublish

Résumé

Individual free fatty acids (FAs) play important roles in metabolic homeostasis, many through engagement with more than 40G protein-coupled receptors. Searching for receptors to sense beneficial omega-3 FAs of fish oil enabled the identification of GPR120, which is involved in a spectrum of metabolic diseases. Here, we report six cryo-electron microscopy structures of GPR120 in complex with FA hormones or TUG891 and G

Identifiants

DOI: 10.1126/science.add6220 PMID: 36862765
pubmed: 36862765
doi: 10.1126/science.add6220
doi:

Substances chimiques

Ligands 0
Receptors, G-Protein-Coupled 0
Fatty Acids, Omega-3 0
FFAR4 protein, human 0
3-(4-((4-fluoro-4'-methyl-(1,1'-biphenyl)-2-yl)methoxy)phenyl)propanoic acid 0
Biphenyl Compounds 0
Phenylpropionates 0
Eicosapentaenoic Acid AAN7QOV9EA

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadd6220

Commentaires et corrections

Type : CommentIn

Auteurs

Chunyou Mao (C)

Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
ORCID: 0000-0001-5349-8592

Peng Xiao (P)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
ORCID: 0000-0002-9809-3481

Xiao-Na Tao (XN)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.
The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
ORCID: 0000-0003-0884-231X

Jiao Qin (J)

Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
ORCID: 0000-0003-4476-5446

Qing-Tao He (QT)

Department of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
ORCID: 0000-0002-0449-2212

Chao Zhang (C)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
ORCID: 0000-0001-8760-0110

Sheng-Chao Guo (SC)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
ORCID: 0000-0002-2758-6019

Ya-Qin Du (YQ)

Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.

Li-Nan Chen (LN)

Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Dan-Dan Shen (DD)

Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
ORCID: 0000-0001-8757-4602

Zhi-Shuai Yang (ZS)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Han-Qiong Zhang (HQ)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Shen-Ming Huang (SM)

Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.

Yong-Hao He (YH)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Jie Cheng (J)

Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Key Laboratory Experimental Teratology of the Ministry of Education and Department of Physiology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China.

Ya-Ni Zhong (YN)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Pan Shang (P)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Physiology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China.

Jun Chen (J)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Dao-Lai Zhang (DL)

School of Pharmacy, Binzhou Medical University, Yantai 264003, China.

Qian-Lang Wang (QL)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Mei-Xia Liu (MX)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Guo-Yu Li (GY)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Yongyuan Guo (Y)

Department of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

H Eric Xu (HE)

CAS Key Laboratory of Receptor Research, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Chuanxin Wang (C)

The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Cheng Zhang (C)

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, the State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China.

Shiqing Feng (S)

The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Department of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
ORCID: 0000-0002-5939-138X

Xiao Yu (X)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Physiology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China.
ORCID: 0000-0003-1119-8334

Yan Zhang (Y)

Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311121, China.
MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Medicine, Hangzhou 310058, China.
Research and Development Center for E-Learning, Ministry of Education, Beijing 100816, China.
ORCID: 0000-0003-2189-0244

Jin-Peng Sun (JP)

Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.
Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
ORCID: 0000-0003-3572-1580

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Unsaturated bond recognition leads to biased...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Unsaturated bond recognition leads to biased...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Unsaturated bond recognition leads to biased...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Unsaturated bond recognition leads to biased...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Unsaturated bond recognition leads to biased...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Dérivés du biphényle › Unsaturated bond recognition leads to biased...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Phénylpropionates › Unsaturated bond recognition leads to biased...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Unsaturated bond recognition leads to biased...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Unsaturated bond recognition leads to biased...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Acide eicosapentanoïque › Unsaturated bond recognition leads to biased...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation faux-sens › Unsaturated bond recognition leads to biased...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Unsaturated bond recognition leads to biased...