Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature.
CD8 T cells
memory
prime-boost interval
transcriptomic profile
vaccination
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
13
09
2022
accepted:
09
01
2023
entrez:
3
3
2023
pubmed:
4
3
2023
medline:
7
3
2023
Statut:
epublish
Résumé
Effective secondary response to antigen is a hallmark of immunological memory. However, the extent of memory CD8 T cell response to secondary boost varies at different times after a primary response. Considering the central role of memory CD8 T cells in long-lived protection against viral infections and tumors, a better understanding of the molecular mechanisms underlying the changing responsiveness of these cells to antigenic challenge would be beneficial. We examined here primed CD8 T cell response to boost in a BALB/c mouse model of intramuscular vaccination by priming with HIV-1 gag-encoding Chimpanzee adenovector, and boosting with HIV-1 gag-encoding Modified Vaccinia virus Ankara. We found that boost was more effective at day(d)100 than at d30 post-prime, as evaluated at d45 post-boost by multi-lymphoid organ assessment of gag-specific CD8 T cell frequency, CD62L-expression (as a guide to memory status) and
Identifiants
pubmed: 36865556
doi: 10.3389/fimmu.2023.1043631
pmc: PMC9973452
doi:
Substances chimiques
Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1043631Subventions
Organisme : Medical Research Council
ID : FC001003
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001003
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001003
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001003
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2023 Natalini, Simonetti, Favaretto, Lucantonio, Peruzzi, Muñoz-Ruiz, Kelly, Contino, Sbrocchi, Battella, Capone, Folgori, Nicosia, Santoni, Hayday and Di Rosa.
Déclaration de conflit d'intérêts
AMC, RS, SB, SC, and AF are employees of ReiThera S.r.l. ANic is named inventor on patent application WO 2005071093 A3 “Chimpanzee adenovirus vaccine carriers”. AF and ANic are equity holders in Keires AG. ACH is a board member and equity holder in ImmunoQure, AG., and Gamma Delta Therapeutics, and is an equity holder in Adaptate Biotherapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that this study received funding from Reithera. Scientific contribution by co-authors affiliated with Reithera is reported in the co-author contribution section.
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