In vitro exposure to environmentally relevant concentrations of norgestrel affects sperm physiology and reproductive success of the Pacific oyster Crassostrea gigas.
Bivalve
DNA damage
Fertilization
Oxidative stress
Progestin
Sperm motility
Journal
Marine environmental research
ISSN: 1879-0291
Titre abrégé: Mar Environ Res
Pays: England
ID NLM: 9882895
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
13
01
2023
revised:
24
02
2023
accepted:
28
02
2023
pubmed:
5
3
2023
medline:
22
3
2023
entrez:
4
3
2023
Statut:
ppublish
Résumé
Progestins in aquatic environments are of increasing concern, as shown by the results of toxicological studies on adult invertebrates with external fertilization. However, their potential effects on the gametes and reproductive success of such animals remain largely unknown. Thus, the current study assessed the effect of in vitro exposure of environmentally relevant concentrations (10 ng/L and 1000 ng/L) of norgestrel (NGT) on the sperm of Pacific oyster Crassostrea gigas, analyzing sperm motility, ultrastructure, mitochondrial function, ATP status, characteristic enzyme activities, and DNA integrity underlying fertilization and hatching success. The results showed that NGT increased the percentage of motile sperm by elevating intracellular Ca
Identifiants
pubmed: 36870161
pii: S0141-1136(23)00066-1
doi: 10.1016/j.marenvres.2023.105938
pii:
doi:
Substances chimiques
Norgestrel
3J8Q1747Z2
Progestins
0
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105938Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.