SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.
HDAC4
SIK3
arousal timing
circadian period
circadian rhythms
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
14 03 2023
14 03 2023
Historique:
entrez:
6
3
2023
pubmed:
7
3
2023
medline:
9
3
2023
Statut:
ppublish
Résumé
Mammals exhibit circadian cycles of sleep and wakefulness under the control of the suprachiasmatic nucleus (SCN), such as the strong arousal phase-locked to the beginning of the dark phase in laboratory mice. Here, we demonstrate that salt-inducible kinase 3 (SIK3) deficiency in gamma-aminobutyric acid (GABA)-ergic neurons or neuromedin S (NMS)-producing neurons delayed the arousal peak phase and lengthened the behavioral circadian cycle under both 12-h light:12-h dark condition (LD) and constant dark condition (DD) without changing daily sleep amounts. In contrast, the induction of a gain-of-function mutant allele of
Identifiants
pubmed: 36877841
doi: 10.1073/pnas.2218209120
pmc: PMC10089210
doi:
Substances chimiques
Arginine Vasopressin
113-79-1
Protein Serine-Threonine Kinases
EC 2.7.11.1
SIK3 protein, mouse
EC 2.7.11.1
Hdac5 protein, mouse
EC 3.5.1.98
Histone Deacetylases
EC 3.5.1.98
Banques de données
figshare
['10.6084/m9.figshare.22138214.v1']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2218209120Subventions
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 22H04918
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