A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 03 2023
07 03 2023
Historique:
received:
11
08
2022
accepted:
27
02
2023
entrez:
7
3
2023
pubmed:
8
3
2023
medline:
10
3
2023
Statut:
epublish
Résumé
Adequate pain management is essential for ethical and scientific reasons in animal experiments and should completely cover the period of expected pain without the need for frequent re-application. However, current depot formulations of Buprenorphine are only available in the USA and have limited duration of action. Recently, a new microparticulate Buprenorphine formulation (BUP-Depot) for sustained release has been developed as a potential future alternative to standard formulations available in Europe. Pharmacokinetics indicate a possible effectiveness for about 72 h. Here, we investigated whether the administration of the BUP-Depot ensures continuous and sufficient analgesia in two mouse fracture models (femoral osteotomy) and could, therefore, serve as a potent alternative to the application of Tramadol via the drinking water. Both protocols were examined for analgesic effectiveness, side effects on experimental readout, and effects on fracture healing outcomes in male and female C57BL/6N mice. The BUP-Depot provided effective analgesia for 72 h, comparable to the effectiveness of Tramadol in the drinking water. Fracture healing outcome was not different between analgesic regimes. The availability of a Buprenorphine depot formulation for rodents in Europe would be a beneficial addition for extended pain relief in mice, thereby increasing animal welfare.
Identifiants
pubmed: 36882427
doi: 10.1038/s41598-023-30641-9
pii: 10.1038/s41598-023-30641-9
pmc: PMC9992384
doi:
Substances chimiques
Buprenorphine
40D3SCR4GZ
Tramadol
39J1LGJ30J
Drinking Water
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3824Informations de copyright
© 2023. The Author(s).
Références
Bone. 2022 Jan;154:116247
pubmed: 34743042
J Orthop Res. 2010 Nov;28(11):1456-62
pubmed: 20872581
Life Sci. 1981 Dec 28;29(26):2699-708
pubmed: 6276633
Lab Anim (NY). 2017 Mar 22;46(4):123-128
pubmed: 28328895
Injury. 2016 Jul;47(7):1435-44
pubmed: 27156834
Behav Brain Res. 2010 Jun 26;210(1):8-15
pubmed: 20122968
J Am Assoc Lab Anim Sci. 2006 May;45(3):12-6
pubmed: 16642964
Acta Biomater. 2019 Mar 1;86:171-184
pubmed: 30616076
Bone. 2003 Sep;33(3):387-98
pubmed: 13678781
Subst Abuse Rehabil. 2016 Jun 14;7:81-6
pubmed: 27366109
J Pediatr Orthop. 2004 Sep-Oct;24(5):463-71
pubmed: 15308893
PLoS One. 2016 May 12;11(5):e0155001
pubmed: 27171143
Contemp Top Lab Anim Sci. 2004 Nov;43(6):42-51
pubmed: 15669134
Bone. 2021 Nov;152:116088
pubmed: 34175502
J Orthop Res. 2005 May;23(3):639-45
pubmed: 15885486
Comp Med. 2019 Dec 1;69(6):490-500
pubmed: 31822324
J Am Assoc Lab Anim Sci. 2014 Jul;53(4):387-91
pubmed: 25199095
Anat Rec (Hoboken). 2014 Oct;297(10):1839-64
pubmed: 24890845
Sci Rep. 2019 Jul 24;9(1):10749
pubmed: 31341225
Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1129-F1137
pubmed: 29357416
J Pharmacol Exp Ther. 2005 Jun;313(3):1136-49
pubmed: 15701707
Curr Neuropharmacol. 2004 Oct;2(4):395-402
pubmed: 18997874
PLoS One. 2017 Jun 15;12(6):e0179588
pubmed: 28617851
Osteoarthritis Cartilage. 2001;9 Suppl A:S91-101
pubmed: 11680695
Comp Med. 2004 Oct;54(5):558-63
pubmed: 15575370
Front Physiol. 2021 Aug 09;12:712494
pubmed: 34434120
FASEB J. 2018 Apr;32(4):2235-2245
pubmed: 29217668
J Am Assoc Lab Anim Sci. 2014 Jan;53(1):24-8
pubmed: 24411776
J Biomed Sci. 2008 Sep;15(5):645-51
pubmed: 18454325
J Biol Regul Homeost Agents. 2019 Nov-Dec;34(4 Suppl. 3):345-351. Congress of the Italian Orthopaedic Research Society
pubmed: 33261299
Contemp Top Lab Anim Sci. 2000 Mar;39(2):8-13
pubmed: 11487232
Eur J Pain. 2004 Oct;8(5):413-25
pubmed: 15324773
Lab Anim (NY). 2009 Mar;38(3):87-93
pubmed: 19229225
Lab Anim. 2002 Jul;36(3):322-43
pubmed: 12144743
Nat Methods. 2010 Jun;7(6):447-9
pubmed: 20453868
Comp Med. 2005 Feb;55(1):37-44
pubmed: 15766208
Sci Rep. 2020 Oct 14;10(1):17295
pubmed: 33057103
Obesity (Silver Spring). 2014 Oct;22(10):2147-55
pubmed: 24942674
Lab Anim. 2013 Jul;47(3):153-61
pubmed: 23563122
J Am Assoc Lab Anim Sci. 2018 Jul 1;57(4):368-375
pubmed: 29871714
Vet J. 2018 Feb;232:70-77
pubmed: 29428096
Comp Med. 2017 Dec 1;67(6):469-482
pubmed: 29212578
Expert Rev Mol Med. 2012 Jan 19;14:e10
pubmed: 22559283
J Orthop Res. 2015 Aug;33(8):1235-41
pubmed: 25876530
Lab Anim (NY). 2012 Nov;41(11):337-43
pubmed: 23079917
Lab Anim. 2015 Jul;49(3):177-87
pubmed: 25488320
Lab Anim. 2016 Dec;50(6):433-441
pubmed: 27909193
Life Sci. 2002 Jul 19;71(9):1023-34
pubmed: 12088762
Toxicol Lett. 1998 Mar 16;95(1):63-71
pubmed: 9650647
PLoS One. 2018 Sep 19;13(9):e0203559
pubmed: 30231081
J Dent Res. 2010 Mar;89(3):219-29
pubmed: 20139336
J Neurosci Methods. 2014 Aug 30;234:139-46
pubmed: 24525328
Acta Pharmacol Sin. 2003 Dec;24(12):1265-9
pubmed: 14653955
Adv Exp Med Biol. 2003;521:117-25
pubmed: 12617570
Vet Anaesth Analg. 2018 Jan;45(1):111-122
pubmed: 29066180
J Vis Exp. 2013 Dec 24;(82):51012
pubmed: 24429701
J Pharmacol Exp Ther. 1995 Feb;272(2):505-10
pubmed: 7853163
Curr Pain Headache Rep. 2014 Oct;18(10):456
pubmed: 25160712
J Am Assoc Lab Anim Sci. 2014 Sep;53(5):478-84
pubmed: 25255070
ILAR J. 2000;41(2):62-71
pubmed: 11304586
J Am Assoc Lab Anim Sci. 2008 Nov;47(6):25-31
pubmed: 19049249
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Appl Anim Behav Sci. 2015 Nov;172:58-62
pubmed: 26937061
Front Immunol. 2019 Apr 12;10:797
pubmed: 31031773