Esmethadone-HCl (REL-1017): a promising rapid antidepressant.
Esketamine
Esmethadone
Ketamine
Major depressive disorder
N-Methyl-D-aspartate receptor
REL-1017
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
28
11
2022
accepted:
13
02
2023
medline:
31
8
2023
pubmed:
9
3
2023
entrez:
8
3
2023
Statut:
ppublish
Résumé
This review article presents select recent studies that form the basis for the development of esmethadone into a potential new drug. Esmethadone is a promising member of the pharmacological class of uncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonists that have shown efficacy for major depressive disorder (MDD) and other diseases and disorders, such as Alzheimer's dementia and pseudobulbar affect. The other drugs in the novel class of NMDAR antagonists with therapeutic uses that are discussed for comparative purposes in this review are esketamine, ketamine, dextromethorphan, and memantine. We present in silico, in vitro, in vivo, and clinical data for esmethadone and other uncompetitive NMDAR antagonists that may advance our understanding of the role of these receptors in neural plasticity in health and disease. The efficacy of NMDAR antagonists as rapid antidepressants may advance our understanding of the neurobiology of MDD and other neuropsychiatric diseases and disorders.
Identifiants
pubmed: 36890259
doi: 10.1007/s00406-023-01571-4
pii: 10.1007/s00406-023-01571-4
pmc: PMC10465385
doi:
Substances chimiques
Excitatory Amino Acid Antagonists
0
Memantine
W8O17SJF3T
Antidepressive Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1463-1476Informations de copyright
© 2023. The Author(s).
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