4D epigenomics: deciphering the coupling between genome folding and epigenomic regulation with biophysical modeling.
Journal
Current opinion in genetics & development
ISSN: 1879-0380
Titre abrégé: Curr Opin Genet Dev
Pays: England
ID NLM: 9111375
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
07
11
2022
revised:
25
01
2023
accepted:
20
02
2023
pubmed:
10
3
2023
medline:
22
3
2023
entrez:
9
3
2023
Statut:
ppublish
Résumé
Recent experimental observations suggest a strong coupling between the 3D nuclear chromosome organization and epigenomics. However, the mechanistic and functional bases of such interplay remain elusive. In this review, we describe how biophysical modeling has been instrumental in characterizing how genome folding may impact the formation of epigenomic domains and, conversely, how epigenomic marks may affect chromosome conformation. Finally, we discuss how this mutual feedback loop between chromatin organization and epigenome regulation, via the formation of physicochemical nanoreactors, may represent a key functional role of 3D compartmentalization in the assembly and maintenance of stable - but yet plastic - epigenomic landscapes.
Identifiants
pubmed: 36893485
pii: S0959-437X(23)00013-8
doi: 10.1016/j.gde.2023.102033
pii:
doi:
Substances chimiques
Chromatin
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102033Informations de copyright
Copyright © 2023. Published by Elsevier Ltd.