Role of Piriform Cortex and Its Afferent Projections in Relapse to Fentanyl Seeking after Food Choice-Induced Voluntary Abstinence.
disconnection
insula
opioid
piriform
prelimbic
relapse
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
05 04 2023
05 04 2023
Historique:
received:
05
01
2023
revised:
15
02
2023
accepted:
20
02
2023
medline:
7
4
2023
pubmed:
11
3
2023
entrez:
10
3
2023
Statut:
ppublish
Résumé
We previously demonstrated a role of piriform cortex (Pir) in relapse to fentanyl seeking after food choice-induced voluntary abstinence. Here, we used this model to further study the role of Pir and its afferent projections in fentanyl relapse. We trained male and female rats to self-administer palatable food pellets for 6 d (6 h/day) and fentanyl (2.5 µg/kg/infusion, i.v.) for 12 d (6 h/day). We assessed relapse to fentanyl seeking after 12 voluntary abstinence sessions, achieved through a discrete choice procedure between fentanyl and palatable food (20 trials/session). We determined projection-specific activation of Pir afferents during fentanyl relapse with Fos plus the retrograde tracer cholera toxin B (injected into Pir). Fentanyl relapse was associated with increased Fos expression in anterior insular cortex (AI) and prelimbic cortex (PL) neurons projecting to Pir. We next used an anatomical disconnection procedure to determine the causal role of these two projections (AI→Pir and PL→Pir) in fentanyl relapse. Contralateral but not ipsilateral disconnection of AI→Pir projections decreased fentanyl relapse but not reacquisition of fentanyl self-administration. In contrast, contralateral but not ipsilateral disconnection of PL→Pir projections modestly decreased reacquisition but not relapse. Fluorescence-activated cell sorting and quantitative PCR data showed molecular changes within Pir Fos-expressing neurons associated with fentanyl relapse. Finally, we found minimal or no sex differences in fentanyl self-administration, fentanyl versus food choice, and fentanyl relapse. Our results indicate that AI→Pir and PL→Pir projections play dissociable roles in nonreinforced relapse to fentanyl seeking versus reacquisition of fentanyl self-administration after food choice-induced voluntary abstinence.
Identifiants
pubmed: 36898838
pii: JNEUROSCI.0034-23.2023
doi: 10.1523/JNEUROSCI.0034-23.2023
pmc: PMC10082459
doi:
Substances chimiques
Fentanyl
UF599785JZ
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2597-2614Subventions
Organisme : NIGMS NIH HHS
ID : FI2 GM142476
Pays : United States
Organisme : NIGMS NIH HHS
ID : TL4 GM118989
Pays : United States
Organisme : NIGMS NIH HHS
ID : FI2 GM128603
Pays : United States
Organisme : NIDA NIH HHS
ID : R25 DA051338
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DA000467
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DA000434
Pays : United States
Informations de copyright
Copyright © 2023 the authors.
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